Shastina G V
Arkh Patol. 1986;48(12):22-9.
Histologic study using semiquantitative analysis and immunofluorescent microscopy of the intestine performed on 278 children of different age who died of acute respiratory, viral and Mycoplasma infections revealed intestinal changes in 168 cases. The incidence and degree of these changes depended on the duration of the disease and the type of the intensive therapy used. Beginning from day 2 of the disease specific changes in the enterocytes in the form of giant-cell metamorphosis were noted. These changes gradually increased reaching their maximum on day 7-9 when in all cases of acute viral respiratory infections microlysis of enterocytes was observed. It was maximal on day 5-6 and inhibited under the influence of intensive therapy. In addition some nonspecific changes were present: circulatory disorders and cellular reaction of the stroma, that changed depending on the duration of the disease being probably a manifestation of a local immune reaction.
对278名死于急性呼吸道、病毒和支原体感染的不同年龄段儿童的肠道进行组织学研究，采用半定量分析和免疫荧光显微镜检查，发现168例存在肠道改变。这些改变的发生率和程度取决于疾病持续时间及所采用的强化治疗类型。从疾病第2天起，就注意到肠细胞出现以巨细胞变形为形式的特异性改变。这些改变逐渐增加，在第7 - 9天达到最大值，此时在所有急性病毒性呼吸道感染病例中均观察到肠细胞微溶解。在第5 - 6天最为明显，并在强化治疗影响下受到抑制。此外，还存在一些非特异性改变：循环障碍和基质的细胞反应，其随疾病持续时间而变化，可能是局部免疫反应的一种表现。
