Crisp A, de Juan E, Tiedeman J
Arch Ophthalmol. 1987 Apr;105(4):546-50. doi: 10.1001/archopht.1987.01060040116047.
Emulsification of intravitreal silicone oil has been observed as a late complication after its use as a retinal tamponade. We compared the emulsification potential of silicone oil of different viscosities (100 centistokes [cs], 1000 cs, and 12,500 cs) and molecular composition in an in vitro model using a commercial detergent (benzalkonium chloride) and physiologic surface-active agents (human serum and lysed red blood cells). We found that silicone oils that have low-molecular-weight contents emulsify more readily than those that do not. Moreover, the extent and susceptibility to emulsification increases with decreasing viscosity or with an increase in the proportion of low-molecular-weight constituents. Hence, higher-molecular-weight (viscosity) oils or removal of low-molecular-weight components from medical grade fluid may lessen the emulsification observed clinically.
玻璃体内硅油乳化是其作为视网膜填塞物使用后的一种晚期并发症。我们在体外模型中，使用商用洗涤剂（苯扎氯铵）和生理性表面活性剂（人血清和裂解红细胞），比较了不同粘度（100厘沲[cs]、1000 cs和12,500 cs）和分子组成的硅油的乳化潜力。我们发现，低分子量含量的硅油比那些没有低分子量含量的硅油更容易乳化。此外，乳化的程度和易感性随着粘度降低或低分子量成分比例增加而增加。因此，高分子量（高粘度）的油或从医用级液体中去除低分子量成分可能会减少临床上观察到的乳化现象。
