Chen Huiying, Zhao Xinshuo, Cui Bingbing, Cui Haohao, Zhao Mengyang, Shi Jun, Li Jingguo, Zhou Zhan
Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, China.
Front Chem. 2023 Mar 9;11:1148354. doi: 10.3389/fchem.2023.1148354. eCollection 2023.
Pathogenic microbial infections have been threatening public health all over the world, which makes it highly desirable to develop an antibiotics-free material for bacterial infection. In this paper, molybdenum disulfide (MoS) nanosheets loaded with silver nanoparticles (Ag NPs) were constructed to inactive bacteria rapidly and efficiently in a short period under a near infrared (NIR) laser (660 nm) in the presence of HO. The designed material presented favorable features of peroxidase-like ability and photodynamic property, which endowed it with fascinating antimicrobial capacity. Compared with free MoS nanosheets, the MoS/Ag nanosheets (denoted as MoS/Ag NSs) exhibited better antibacterial performance against by the generated reactive oxygen species (ROS) from both peroxidase-like catalysis and photodynamic, and the antibacterial efficiency of MoS/Ag NSs could be further improved by increasing the amount of Ag. Results from cell culture tests proved that MoS/Ag3 nanosheets had a negligible impact on cell growth. This work provided new insight into a promising method for eliminating bacteria without using antibiotics, and could serve as a candidate strategy for efficient disinfection to treat other bacterial infections.
致病性微生物感染一直威胁着全球公众健康，这使得开发一种用于细菌感染的无抗生素材料变得非常迫切。在本文中，构建了负载银纳米颗粒（Ag NPs）的二硫化钼（MoS）纳米片，以在近红外（NIR）激光（660 nm）照射下，在HO存在的情况下，在短时间内快速有效地使细菌失活。所设计的材料具有类过氧化物酶能力和光动力特性等良好特性，这赋予了它迷人的抗菌能力。与游离的MoS纳米片相比，MoS/Ag纳米片（表示为MoS/Ag NSs）通过类过氧化物酶催化和光动力产生的活性氧（ROS）对表现出更好的抗菌性能，并且通过增加Ag的量可以进一步提高MoS/Ag NSs的抗菌效率。细胞培养测试结果证明，MoS/Ag3纳米片对细胞生长的影响可以忽略不计。这项工作为一种不使用抗生素消除细菌的有前途的方法提供了新的见解，并可作为一种有效的消毒策略来治疗其他细菌感染。
