2020 年 6 月至 2021 年 5 月德国儿童中 SARS-CoV-2 抗体的横断面血清流行率调查。
Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021.
机构信息
Institute of Social Paediatrics and Adolescent Medicine, Division of Paediatric Epidemiology, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
University Children's Hospital, Eberhard Karls University, 72076, Tuebingen, Germany.
出版信息
Nat Commun. 2022 Jun 6;13(1):3128. doi: 10.1038/s41467-022-30482-6.
The rate of SARS-CoV-2 infections in children remains unclear due to many asymptomatic cases. We present a study of cross-sectional seroprevalence surveys of anti-SARS-CoV-2 IgG in 10,358 children recruited in paediatric hospitals across Germany from June 2020 to May 2021. Seropositivity increased from 2.0% (95% CI 1.6, 2.5) to 10.8% (95% CI 8.7, 12.9) in March 2021 with little change up to May 2021. Rates increased by migrant background (2.8%, 4.4% and 7.8% for no, one and two parents born outside Germany). Children under three were initially 3.6 (95% CI 2.3, 5.7) times more likely to be seropositive with levels equalising later. The ratio of seropositive cases per recalled infection decreased from 8.6 to 2.8. Since seropositivity exceeds the rate of recalled infections considerably, serologic testing may provide a more valid estimate of infections, which is required to assess both the spread and the risk for severe outcomes of SARS-CoV-2 infections.
由于许多无症状病例，儿童中 SARS-CoV-2 感染的发生率仍不清楚。我们报告了一项横断面血清流行率调查研究，该研究在 2020 年 6 月至 2021 年 5 月期间在德国各地的儿童医院招募了 10358 名儿童，检测其针对 SARS-CoV-2 IgG 的血清抗体。血清阳性率从 2021 年 3 月的 2.0%（95%CI 1.6，2.5）增加到 10.8%（95%CI 8.7，12.9），直到 2021 年 5 月变化不大。移民背景的血清阳性率也有所增加（无、一个和两个父母均在德国境外出生的儿童的血清阳性率分别为 2.8%、4.4%和 7.8%）。三岁以下儿童最初感染 SARS-CoV-2 的血清阳性率为 3.6 倍（95%CI 2.3，5.7），但后来水平趋于平衡。回忆性感染的血清阳性病例比例从 8.6 下降到 2.8。由于血清阳性率大大超过了回忆性感染的发生率，血清学检测可能为感染提供更准确的估计，这对于评估 SARS-CoV-2 感染的传播和严重后果的风险是必要的。
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