CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
Adv Healthc Mater. 2022 Aug;11(15):e2200653. doi: 10.1002/adhm.202200653. Epub 2022 Jun 19.
Hydrogel-based epidermal electrodes attract widespread attention in health monitoring and human-machine interfaces for their good biocompatibility, skin-matched Young's modulus, and stable in situ electrophysiological recording performance. However, it is difficult to make the exact conformal attachment between skin and electrodes because of the hair, wrinkles, as well as complex, curved contours of the skin. This also results in signal distortion and large noise. Here, a body temperature enhanced skin-adhesive epidermal electrode is proposed based on non-covalent cross-linked network ionic hydrogel. The ionic hydrogel is fabricated by the polyvinyl alcohol, branched polyethyleneimine, and calcium chloride (CaCl ), which demonstrates impressive performances including ultra-stretchability of 1291%, great adhesion to skin and other non-biological materials, stable conductivity of 3.09 S m , recyclability, and outstanding antibacterial ability, simultaneously. Specifically, the adhesion of the ionic hydrogel behaves as temperature-sensitive and could be enhanced by body temperature. Furthermore, the ionic hydrogel is utilized as epidermal electrodes, which display seductive capability to record multifarious electrophysiological signals with high signal-to-noise ratio and ultra-low detection limit, including electrocardiogram, electromyogram, and electroencephalogram. The as-proposed body temperature enhanced skin-adhesive ionic hydrogel brings intelligent functions and broadens the way for epidermal electronics, promoting the development of healthcare electronics.
基于水凝胶的表皮电极因其良好的生物相容性、与皮肤相匹配的杨氏模量以及稳定的原位电生理记录性能，在健康监测和人机界面中受到广泛关注。然而，由于毛发、皱纹以及皮肤复杂的弯曲轮廓，很难使皮肤和电极之间实现精确的贴合。这也导致信号失真和较大的噪声。本文提出了一种基于非共价交联网络离子水凝胶的体温增强型皮肤贴合表皮电极。该离子水凝胶由聚乙烯醇、支化聚乙烯亚胺和氯化钙（CaCl 2 ）制备而成，具有超拉伸性（可拉伸 1291%）、对皮肤和其他非生物材料的超强附着力、稳定的电导率（3.09 S m -1 ）、可回收性和出色的抗菌能力。具体来说，离子水凝胶的附着力表现出对温度的敏感性，可以通过体温增强。此外，离子水凝胶被用作表皮电极，具有诱人的能力，可以记录具有高信噪比和超低检测限的多种电生理信号，包括心电图、肌电图和脑电图。所提出的体温增强型皮肤贴合离子水凝胶带来了智能功能，拓宽了表皮电子学的途径，促进了医疗保健电子学的发展。
