EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture.

BACKGROUND

In previous studies, electroacupuncture (EA) with 2/15 Hz has been shown to enhance the sedative effects in general anesthesia patients. Central lateral thalamic stimulation of 50 Hz showed an arousal effect in macaques. Therefore, it is worth studying the sedative effect of EA at peripheral acupoints with different frequencies, especially the frequency of around 50 Hz.

METHODS

Rats were anesthetized under the constant infusion of propofol and EA at (ST36) and (PC6) locations. Electroencephalography (EEG) and heart rate were continuously recorded before and after the intervention by EA in the group (control), group (low-frequency group, 2/15 Hz diffuse/dense wave EA stimulation), and group (high-frequency group, 50 Hz stimulation).

RESULTS

In the group, a significant increase in the power of the delta component with a decrease in the alpha component ( < 0.05) was observed after EA stimulation. In the group, significant increases in the powers of alpha and beta components of EEG ( < 0.05) and a decrease in the delta component of EEG were observed ( < 0.05). The phenomenon is also shown in full-frequency waves. In addition, a significant decrease in the low-frequency/high-frequency ratio parameter was observed in the group.

CONCLUSIONS

EA at bilateral ST36 and PC6 can enhance the sedative effects of propofol anesthesia in low-frequency stimulation but lighten the sedative effects in high-frequency (50 Hz) stimulation. The sympathetic-vagal balance was affected due to low-frequency EA.