Ansari Narges, Jahangiri Mina, Shirbandi Kimia, Ebrahimi Mina, Rahim Fakher
Department of Internal Medicine, Isfahan Bone Metabolic Disorders Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Biostatistics and Epidemiology, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Bull Natl Res Cent. 2022;46(1):158. doi: 10.1186/s42269-022-00844-7. Epub 2022 May 31.
Immunocompromised individuals are expected to be more prone to severe diseases and, subsequently, death. Genetic disorders and polymorphisms in genes involved in the immune system, such as human leukocyte antigen (HLA), inflammatory cytokines, and killer-cell immunoglobulin-like receptors, can be involved in the immune system's response to various pathogens. In the current survey, the data were received from the world health organization, collected around the world.
Spearman's coefficient correlation test for evaluating the relationship between the Daily Death Rates (DDR) and immunological variables showed a statistically significant correlation between the DDR and all immunological variables except TNFa857T, TNFa863A IL2330G, and IL2166T ( < 0.001). Also, there was a statistically significant correlation between the DDR and some HLA markers.
This meta-analysis study shows that predictive biomarkers and mortality of COVID-19 are associated with HLA markers. However, these results should be confirmed in a more structured agreement. It is worth noting that the design of new studies should consider potential diseases with poor prognoses because they are related to these immune genetic markers.
The online version contains supplementary material available at 10.1186/s42269-022-00844-7.
免疫功能低下的个体预计更容易患严重疾病，进而导致死亡。免疫系统中涉及的基因的遗传疾病和多态性，如人类白细胞抗原（HLA）、炎性细胞因子和杀伤细胞免疫球蛋白样受体，可能参与免疫系统对各种病原体的反应。在本次调查中，数据来自世界卫生组织，是在全球范围内收集的。
用于评估每日死亡率（DDR）与免疫学变量之间关系的Spearman系数相关性检验显示，DDR与除TNFa857T、TNFa863A、IL2330G和IL2166T之外的所有免疫学变量之间存在统计学显著相关性（<0.001）。此外，DDR与一些HLA标记之间也存在统计学显著相关性。
这项荟萃分析研究表明，COVID-19的预测生物标志物和死亡率与HLA标记有关。然而，这些结果应在更严谨的研究中得到证实。值得注意的是，新研究的设计应考虑到预后不良的潜在疾病，因为它们与这些免疫遗传标记有关。
在线版本包含可在10.1186/s42269-022-00844-7获取的补充材料。
