Su Lingying, Li Sai, Sun Bo
Department of Neurology, The Affiliated Huaian No. 1 Hospital of Nanjing Medical University, Huaian 223300, China.
Department of Pharmacy, Huaian Women and Children's Health Care Hospital, Huaian 223003, China.
Emerg Med Int. 2022 May 28;2022:1076053. doi: 10.1155/2022/1076053. eCollection 2022.
The aim is to study the curative effect of prebiotics/probiotics-assisted ketogenic diet (KD) on children with refractory epilepsy.
A retrospective analysis was performed on the clinical data of 80 children with refractory epilepsy treated in the hospital between December 2018 and December 2020. According to different treatment methods, they were divided into the KD group (36 cases, KD) and combination group (44 cases, prebiotics/probiotics assisted KD). All were followed up for 1 year. The curative effect, electroencephalogram findings, levels of neurotransmitters, quality of life scores, cognitive function (verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ)), and incidence of adverse reactions were compared between the two groups.
At the last follow-up, the effective rate of the combination group was higher than that of the KD group (95.45% 80.56%) ( < 0.05). After 1 year of treatment, video electroencephalogram findings in both groups were improved, and the response rate of the combination group was higher than that of the KD group (97.73% 83.33%) ( < 0.05). After 1 year of treatment, levels of VIQ and PIQ in both groups were increased, which were higher in the combination group than the KD group ( < 0.05). After 1 year of treatment, the level of 5-hydroxytryptamine (5-HT) in both groups was increased, which was higher in the combination group than the KD group ( < 0.05). After 1 year of treatment, quality of life scores in both groups were increased, which was higher in the combination group than the KD group ( < 0.05). The incidence of adverse reactions in the combination group was lower than that in the KD group (13.64% 36.11%) ( < 0.05).
The curative effect of prebiotics/probiotics-assisted KD is better on children with refractory epilepsy, which can effectively improve electroencephalogram and quality of life, increase neurotransmitters and cognitive levels, with good safety.
研究益生元/益生菌辅助生酮饮食（KD）对难治性癫痫患儿的疗效。
对2018年12月至2020年12月在我院治疗的80例难治性癫痫患儿的临床资料进行回顾性分析。根据不同治疗方法，将其分为KD组（36例，采用KD治疗）和联合组（44例，采用益生元/益生菌辅助KD治疗）。所有患儿均随访1年。比较两组的疗效、脑电图结果、神经递质水平、生活质量评分、认知功能（言语智商（VIQ）、操作智商（PIQ））及不良反应发生率。
末次随访时，联合组有效率高于KD组（95.45%对80.56%）（P<0.05）。治疗1年后，两组视频脑电图结果均有改善，联合组有效率高于KD组（97.73%对83.33%）（P<0.05）。治疗1年后，两组VIQ和PIQ水平均升高，联合组高于KD组（P<0.05）。治疗1年后，两组5-羟色胺（5-HT）水平均升高，联合组高于KD组（P<0.05）。治疗1年后，两组生活质量评分均升高，联合组高于KD组（P<0.05）。联合组不良反应发生率低于KD组（13.64%对36.11%）（P<0.05）。
益生元/益生菌辅助KD治疗难治性癫痫患儿疗效更佳，可有效改善脑电图及生活质量，提高神经递质及认知水平，安全性良好。
