Suriñach-Ayats Bruna, Carbonell-Estarellas Emma, Becerra-Hervas Judit, López-Bernal Esther, Boronat Susana, Moliner-Calderon Elisenda
Hospital de la Santa Creu i Sant Pau, Barcelona, España.
Enferm Infecc Microbiol Clin. 2022 May 13. doi: 10.1016/j.eimc.2022.04.009.
SARS-CoV-2 infection during pregnancy and its impact on the newborn were, in the first months of the pandemic, unknown. Recent studies have provided information on the clinical involvement in the newborn and its evolution.This work shows how passive immunity varies in the newborn in relation to the moment of maternal SARS-CoV-2 infection during pregnancy.
Observational, prospective and longitudinal study in a third level hospital. Epidemiological and clinical data from mothers and their newborns were collected from May 2020 to June 2021.
A total of 109 mothers and 109 neonates have been included. 28.4% of maternal infections were in the first trimester, 24.8% during the second and 58.8% in the third. 56% of maternal infections were symptomatic and only one pregnant woman with severe respiratory infection was admitted to intensive care. The mean gestational age of the newborns was 39 weeks, with a mean weight of 3232 g and a head circumference of 35 cm. Eight newborns born from mothers with SARS-CoV-2 required admission to the neonatal ICU: 2 due to jaundice, 2 due to respiratory distress, 1 due to moderate prematurity, and 3 due to other causes unrelated to infection attributable to SARS-CoV-2. IgG-type antibodies were positive in 56.9% of newborns. Of the mothers infected during the 1 st trimester, IgG were positive in 32.2% of the newborns, in the second trimester 81.5% were positive and in the third 58.8%. No neonate had positive IgM.
SARS-CoV-2 infection during pregnancy provides IgG antibodies to half of newborns. The presence of antibodies in the newborn is more likely when the infection has occurred in the second trimester of pregnancy.
在疫情的最初几个月里，妊娠期的新型冠状病毒2（SARS-CoV-2）感染及其对新生儿的影响尚不清楚。近期研究已提供了关于新生儿临床受累情况及其演变的信息。本研究展示了新生儿的被动免疫如何因母亲在妊娠期感染SARS-CoV-2的时间不同而有所变化。
在一家三级医院进行的观察性、前瞻性和纵向研究。收集了2020年5月至2021年6月期间母亲及其新生儿的流行病学和临床数据。
共纳入109名母亲和109名新生儿。28.4%的母亲感染发生在孕早期，24.8%发生在孕中期，58.8%发生在孕晚期。56%的母亲感染有症状，仅有一名患有严重呼吸道感染的孕妇被收入重症监护病房。新生儿的平均胎龄为39周，平均体重为3232克，头围为35厘米。8名母亲感染SARS-CoV-2的新生儿需要入住新生儿重症监护病房：2名因黄疸，2名因呼吸窘迫，1名因中度早产，3名因与SARS-CoV-2感染无关的其他原因。56.9%的新生儿IgG型抗体呈阳性。在孕早期感染的母亲中，32.2%的新生儿IgG呈阳性，孕中期感染的母亲中81.5%的新生儿IgG呈阳性，孕晚期感染的母亲中58.8%的新生儿IgG呈阳性。没有新生儿IgM呈阳性。
妊娠期的SARS-CoV-2感染为一半的新生儿提供了IgG抗体。当感染发生在妊娠中期时，新生儿更有可能存在抗体。
