Sahni R S, Paparella M M, Schachern P A, Goycoolea M V, Le C T
Arch Otolaryngol Head Neck Surg. 1987 Jun;113(6):630-4. doi: 10.1001/archotol.1987.01860060056015.
The thickness and morphologic characteristics of the round window membrane were evaluated in temporal bones from normal subjects as well as those with serous otitis media, purulent otitis media, and chronic otitis media. Temporal bones were studied in chronological order in six age ranges to determine the possibility of age-related differences. No significant difference in the mean thickness of the round window membrane was observed in terms of age groups in normal temporal bones or temporal bones from patients with otitis media; however, a significant difference in the mean thickness was observed in the various forms of otitis media compared with the normal round window membrane in all age groups. The membrane was thickest in patients with chronic otitis media when compared with that in normal subjects or those with serous or purulent otitis media. The epithelial layer (including the subepithelial space) and the fibrous layer were measured individually to determine in which layer the change in mean thickness occurred. These measurements showed an involvement of all layers of the round window membrane in those groups with otitis media, with maximal involvement of the combined epithelial layer and subepithelial space.
在正常受试者以及患有浆液性中耳炎、化脓性中耳炎和慢性中耳炎的受试者的颞骨中，评估圆窗膜的厚度和形态学特征。按时间顺序在六个年龄范围内研究颞骨，以确定年龄相关差异的可能性。在正常颞骨或中耳炎患者的颞骨中，未观察到圆窗膜平均厚度在年龄组方面有显著差异；然而，与所有年龄组的正常圆窗膜相比，在各种形式的中耳炎中观察到平均厚度有显著差异。与正常受试者或患有浆液性或化脓性中耳炎的受试者相比，慢性中耳炎患者的圆窗膜最厚。分别测量上皮层（包括上皮下间隙）和纤维层，以确定平均厚度变化发生在哪一层。这些测量结果表明，中耳炎组圆窗膜的所有层均受累，上皮层和上皮下间隙的联合受累最为严重。
