Paparella M M, Schachern P A, Yoon T H, Abdelhammid M M, Sahni R, da Costa S S
University of Minnesota Otitis Media Research Center, Minneapolis.
Ann Otol Rhinol Laryngol Suppl. 1990 Jun;148:17-22. doi: 10.1177/00034894900990s606.
It has been our hypothesis that different types of middle ear effusions and the clinical manifestations with which they are associated represent the typical inflammatory response. Employing an animal model under controlled conditions, we present statistical evidence that change in the mucosa of the middle ear in otitis media can occur along a continuum, with early forms regressing to more chronic stages of the disease. We also demonstrate an increase in the thickness and a decrease in the permeability of the round window membrane in a longitudinal study of otitis media in the same animal model. Histopathologic changes in human temporal bones with otitis media with effusion or chronic otitis media are similar to the changes in the animal models. These results support a concept that all categories of otitis media (serous, purulent, mucoid, and chronic) represent different stages in a continuum of events.
我们的假设是，不同类型的中耳积液及其相关的临床表现代表了典型的炎症反应。在可控条件下利用动物模型，我们提供了统计学证据，表明中耳炎时中耳黏膜的变化可呈连续性，早期形式可发展为疾病的更慢性阶段。在对同一动物模型的中耳炎纵向研究中，我们还证明了圆窗膜厚度增加和通透性降低。患有渗出性中耳炎或慢性中耳炎的人类颞骨的组织病理学变化与动物模型中的变化相似。这些结果支持了一个概念，即所有类型的中耳炎（浆液性、脓性、黏液性和慢性）代表了一系列连续事件中的不同阶段。
