喹诺酮衍生物对茶碱清除率的影响。
The influence of quinolone derivatives on theophylline clearance.
作者信息
Wijnands W J, Vree T B, van Herwaarden C L
出版信息
Br J Clin Pharmacol. 1986 Dec;22(6):677-83. doi: 10.1111/j.1365-2125.1986.tb02957.x.
Enoxacin decreases the metabolic clearance of the bronchodilator theophylline not only in severely ill patients, but also in patients with stable chronic obstructive airways disease. In this comparative study, significantly increased plasma theophylline concentrations were measured during co-administration of enoxacin (110.9%) and, to a lesser degree, also during co-administration of pefloxacin (19.6%) and ciprofloxacin (22.8%). Total body clearance of theophylline was significantly decreased by enoxacin (63.6%), ciprofloxacin (30.4%) and pefloxacin (29.4%). The pharmacokinetic parameters of theophylline did not change during co-administration of ofloxacin and nalidixic acid. There is growing evidence that the observed interaction is caused not by the parent drugs, but by the 4-oxo metabolite of enoxacin, pefloxacin and ciprofloxacin.
依诺沙星不仅会降低重症患者体内支气管扩张剂茶碱的代谢清除率，对于患有稳定型慢性阻塞性气道疾病的患者也是如此。在这项对照研究中，同时服用依诺沙星时，血浆茶碱浓度显著升高（110.9%），同时服用培氟沙星（19.6%）和环丙沙星（22.8%）时，血浆茶碱浓度也有一定程度的升高。依诺沙星（63.6%）、环丙沙星（30.4%）和培氟沙星（29.4%）均使茶碱的总体清除率显著降低。同时服用氧氟沙星和萘啶酸时，茶碱的药代动力学参数未发生变化。越来越多的证据表明，观察到的相互作用并非由母体药物引起，而是由依诺沙星、培氟沙星和环丙沙星的4-氧代代谢物所致。
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