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A cytotoxic DNA precursor is taken up selectively by human cancer xenografts.

作者信息

Bagshawe K D, Boden J, Boxer G M, Britton D W, Green A, Partridge T, Pedley B, Sharma S, Southall P

出版信息

Br J Cancer. 1987 Mar;55(3):299-302. doi: 10.1038/bjc.1987.58.

DOI:10.1038/bjc.1987.58
PMID:3567064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2001750/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de1/2001750/2d2831af13ad/brjcancer00514-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de1/2001750/2d2831af13ad/brjcancer00514-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de1/2001750/2d2831af13ad/brjcancer00514-0069-a.jpg

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A cytotoxic DNA precursor is taken up selectively by human cancer xenografts.一种具有细胞毒性的DNA前体被人癌异种移植瘤选择性摄取。
Br J Cancer. 1987 Mar;55(3):299-302. doi: 10.1038/bjc.1987.58.
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Selective uptake of toxic nucleoside (125IUdR) by resistant cancer.
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Gallium uptake in heterotransplanted human choriocarcinoma and ovarian carcinoma in nude mice.裸鼠异种移植人绒毛膜癌和卵巢癌中镓的摄取情况。
Proc Soc Exp Biol Med. 1980 Nov;165(2):361-3. doi: 10.3181/00379727-165-40986.
4
[Effect of various chemotherapeutic agents on DNA synthesis in the cells of human strains of breast and laryngeal cancer, chorionepithelioma and Wilms' tumor].
Biull Eksp Biol Med. 1981 Oct;91(10):469-71.
5
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6
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The stimulation by methotrexate of human chorionic gonadotropin and placental alkaline phosphatase in cultured choriocarcinoma cells.甲氨蝶呤对培养的绒毛膜癌细胞中人绒毛膜促性腺激素和胎盘碱性磷酸酶的刺激作用。
Cancer Res. 1976 Dec;36(12):4570-6.
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[Level of 5-fluorouracil in cancerous and normal tissues of nude mice bearing human endometrial carcinoma after administration of UFT coadministered with nicardipin].[联合使用尼卡地平的优福定给药后，荷人子宫内膜癌裸鼠癌组织和正常组织中5-氟尿嘧啶的水平]
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引用本文的文献

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Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2'-deoxyuridine, 5-iodo-3'-fluoro-2',3'-dideoxyuridine, and 3'-fluorothymidine for molecular radiotherapy of cancer: synthesis and biological evaluation.放射性标记的环沙立醇单磷酸酯 5-碘-2'-脱氧尿苷、5-碘-3'-氟-2',3'-二脱氧尿苷和 3'-氟胸苷用于癌症的分子放疗：合成与生物学评价。
J Med Chem. 2012 Mar 22;55(6):2649-71. doi: 10.1021/jm201482p. Epub 2012 Mar 8.
2
The influence of high dose hydroxyurea on the incorporation of 5-iodo-2-deoxyuridine (IUdR) by human bone marrow and tumour cells in vivo.高剂量羟基脲对人骨髓和肿瘤细胞在体内摄取5-碘-2-脱氧尿苷（IUdR）的影响。
Br J Cancer. 1993 Apr;67(4):644-9. doi: 10.1038/bjc.1993.120.
3

本文引用的文献

1
A REVIEW OF SOME ASPECTS OF 5-IODODEOXYURIDINE AND AZAURIDINE.
Cancer Res. 1963 Sep;23:1246-59.
2
Genetics of human cell lines. III. Incorporation of 5-bromo- and 5-iododeoxyuridine into the deoxyribonucleic acid of human cells and its effect on radiation sensitivity.人类细胞系的遗传学。III. 5-溴脱氧尿苷和5-碘脱氧尿苷掺入人类细胞的脱氧核糖核酸及其对辐射敏感性的影响。
J Exp Med. 1960 Sep 1;112(3):509-31. doi: 10.1084/jem.112.3.509.
3
Administration of 5-iododeoxyuridine-I-131 in the mouse and rat.在小鼠和大鼠中给予5-碘脱氧尿苷-I-131。
In vivo uptake of 131I-5-iodo-2-deoxyuridine by malignant tumours in man.
人体内恶性肿瘤对131I - 5 -碘-2 -脱氧尿苷的体内摄取。
Br J Cancer. 1991 Jan;63(1):134-5. doi: 10.1038/bjc.1991.27.
Cancer Res. 1961 Apr;21:345-52.
4
Synthesis and biological activities of iododeoxyuridine, an analog of thymidine.胸腺嘧啶核苷类似物碘脱氧尿苷的合成及生物活性
Biochim Biophys Acta. 1959 Mar;32(1):295-6. doi: 10.1016/0006-3002(59)90597-9.
5
Different activities of unscheduled DNA synthesis in human melanoma and bone marrow cells.人类黑色素瘤细胞和骨髓细胞中DNA非定时合成的不同活性。
Cancer Res. 1982 Jan;42(1):84-8.
6
Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells.羟基脲抗性小鼠成纤维细胞3T6中核糖核苷酸还原酶自由基的过度产生。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2159-63. doi: 10.1073/pnas.78.4.2159.
7
Drug resistance in cancer.癌症中的耐药性。
Cancer Treat Rep. 1984 Jan;68(1):87-99.
8
Therapeutic effects of hydroxyurea. Experience with 118 patients with inoperable solid tumors.羟基脲的治疗效果。118例无法手术的实体瘤患者的经验。
Cancer. 1970 Mar;25(3):705-14. doi: 10.1002/1097-0142(197003)25:3<705::aid-cncr2820250331>3.0.co;2-d.
9
Alternative de novo and "salvage" pathways to thymidine triphosphate synthesis: possible implications for cancer chemotherapy.
Cancer Res. 1969 Dec;29(12):2398-403.
10
Incorporation of 131 iododeoxyuridine into the DNA of tumour-bearing rats after partial synchronization as a tool in scintigraphic tumour localization.部分同步化后将131碘脱氧尿苷掺入荷瘤大鼠的DNA中作为肿瘤闪烁定位的一种手段。
Nucl Med (Stuttg). 1974 Jan 15;12(4):309-19.