Department of Internal Medicine, Veterinary Faculty, Adnan Menderes University, Aydın, Turkey.
Department of Biochemistry, Veterinary Faculty, Adnan Menderes University, Aydın, Turkey.
Vet Dermatol. 2022 Oct;33(5):378-383. doi: 10.1111/vde.13095. Epub 2022 Jun 7.
Information on acute-phase protein (APP) concentrations in dogs with sarcoptic mange (SM) is scarce.
To determine the effects of the clinical severity of disease and concomitant pyoderma on serum C-reactive protein (CRP), serum amyloid-A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) concentrations in dogs with SM.
Forty client-owned dogs with SM (INF group) and 10 healthy control dogs (CON group).
The INF group was divided into three subgroups; Group 1 (mild/moderate), Group 2 (severe) and Group 3 (severe+pyoderma) according to the extent of skin lesions and the presence of concomitant pyoderma. Serum CRP, SAA, Hp and Cp concentrations of all study groups were measured.
Serum CRP (P < 0.001), SAA (P < 0.001) and Hp (P = 0.016) concentrations of the INF group were higher than the CON group, with no difference in terms of Cp. A statistical difference was measured between groups 2 and 1 in SAA only. C-reactive protein was found to be significantly higher in dogs with severe SM accompanied by pyoderma (Group 3) when compared with dogs with severe SM (Group 2). The area under the receiver-operating characteristic curves differentiating pyoderma among dogs with severe SM was 0.850 for CRP (P = 0.0001, cut-off value >61.3 mg/L with sensitivity 69.29% and specificity 90.91%).
The unique findings in this were that the SAA serum concentrations are related to the severity of SM and that serum CRP concentrations are effective in detecting the presence of pyoderma in dogs with severe SM.
有关患有疥螨病（SM）的犬的急性期蛋白（APP）浓度的信息很少。
确定疾病临床严重程度和伴发脓皮病对患有 SM 的犬的血清 C 反应蛋白（CRP）、血清淀粉样蛋白 A（SAA）、触珠蛋白（Hp）和铜蓝蛋白（Cp）浓度的影响。
40 只患有 SM 的患犬（INF 组）和 10 只健康对照犬（CON 组）。
根据皮肤病变的程度和伴发脓皮病的情况，将 INF 组分为三个亚组；第 1 组（轻度/中度）、第 2 组（严重）和第 3 组（严重+脓皮病）。测量所有研究组的血清 CRP、SAA、Hp 和 Cp 浓度。
INF 组的血清 CRP（P<0.001）、SAA（P<0.001）和 Hp（P=0.016）浓度高于 CON 组，而 Cp 则无差异。仅在 SAA 方面，组 2 和组 1 之间存在统计学差异。与仅患有严重 SM 的犬（组 2）相比，患有严重 SM 伴发脓皮病的犬（组 3）的 CRP 显著升高。区分严重 SM 犬脓皮病的受试者工作特征曲线下面积为 CRP 的 0.850（P=0.0001，临界值>61.3 mg/L，敏感性 69.29%，特异性 90.91%）。
本研究的独特发现是 SAA 血清浓度与 SM 的严重程度有关，而 CRP 血清浓度可有效检测严重 SM 犬中脓皮病的存在。
