Real Eliana, Mancio-Silva Liliana
Institut Pasteur, Université Paris Cité, Inserm U1201, CNRS EMR9195, Unité de Biologie des Interactions Hôte-Parasite, F-75015 Paris, France.
Institut Pasteur, Université Paris Cité, Inserm U1201, CNRS EMR9195, Unité de Biologie des Interactions Hôte-Parasite, F-75015 Paris, France.
Trends Parasitol. 2022 Sep;38(9):748-757. doi: 10.1016/j.pt.2022.05.009. Epub 2022 Jun 4.
Malaria-causing Plasmodium parasites undergo multiple phenotypic transitions as they cycle between diverse niches in the mammalian and mosquito hosts. Recent applications of single-cell technologies to Plasmodium have enabled the systematic investigation of the distinct stages across the life cycle. Most single-cell data have focused on the parasite exclusively, but a few studies have started to profile both parasite and host cells to shed light on the heterogeneity of cell states that underpin host-parasite interactions. In this opinion article, we highlight how atlasing initiatives are starting to be used to infer functional interactions between parasite and host and could be a powerful tool in drug discovery and vaccine development.
导致疟疾的疟原虫寄生虫在哺乳动物和蚊子宿主的不同生态位之间循环时会经历多种表型转变。最近将单细胞技术应用于疟原虫使得能够对整个生命周期中的不同阶段进行系统研究。大多数单细胞数据仅专注于寄生虫，但也有一些研究开始对寄生虫和宿主细胞进行分析，以揭示支撑宿主-寄生虫相互作用的细胞状态异质性。在这篇观点文章中，我们强调图谱计划如何开始被用于推断寄生虫与宿主之间的功能相互作用，并且可能成为药物发现和疫苗开发中的有力工具。
