处于精准医学前沿的基因组医学。
Genomic medicine on the frontier of precision medicine.
作者信息
Hasanzad Mandana, Sarhangi Negar, Naghavi Anoosh, Ghavimehr Ehsan, Khatami Fatemeh, Ehsani Chimeh Sima, Larijani Bagher, Aghaei Meybodi Hamid Reza
机构信息
Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No.10- Jalal -e-Ale-Ahmad Street, Chamran Highway, 1411713119 Tehran, Iran.
出版信息
J Diabetes Metab Disord. 2021 Aug 24;21(1):853-861. doi: 10.1007/s40200-021-00880-6. eCollection 2022 Jun.
Genomic medicine has created a great deal of hope since the completion of the Human Genome Project (HGP). Genomic medicine promises disease prevention and early diagnosis in the context of precision medicine. Precision medicine as a scientific discipline has introduced as an evolution in medicine. The rapid growth of high-development technologies permits the assessment of biological systems. Study of the integrated profiles of omics, such as genome, transcriptome, proteome and other omics information lead to significant advances in personalized and precision medicine. In the context of precision medicine, pharmacogenomics can play an important role in order to discriminate responders and non-responders to medications and avoiding toxicity and achieving the optimum dose. So precision medicine in accordance with genomic medicine will transform medicine from conventional evidence-based medicine in the diagnosis and treatment towards precision based-medicine. In this review, we have summarized the related issues for genomic medicine and precision medicine.
自人类基因组计划（HGP）完成以来，基因组医学带来了诸多希望。基因组医学有望在精准医学的背景下实现疾病预防和早期诊断。精准医学作为一门科学学科，是医学领域的一次变革。高科技的快速发展使得对生物系统的评估成为可能。对基因组、转录组、蛋白质组等组学综合图谱以及其他组学信息的研究，推动了个性化和精准医学的重大进展。在精准医学的背景下，药物基因组学能够在区分药物反应者和无反应者、避免毒性以及实现最佳剂量方面发挥重要作用。因此，与基因组医学相结合的精准医学将把医学从传统的基于证据的诊断和治疗模式转变为基于精准的医学模式。在本综述中，我们总结了基因组医学和精准医学的相关问题。
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