Rezaeinezhad Najmeh, Alizadeh Rostam, Ghanbari-Niaki Abbas
Department of Sports Science, School of Literature and Humanities, Ilam University, Ilam, I.R Iran.
Department of Exercise Biochemistry Division, Faculty of Sport Sciences, University of Mazandaran, Babolsar, I.R Iran.
J Diabetes Metab Disord. 2022 Mar 17;21(1):583-588. doi: 10.1007/s40200-022-01020-4. eCollection 2022 Jun.
The underlying mechanism of exercise-induced insulin resistance (IR) improvement is unclear. Adropin is a multifunctional peptide has a significant role in the regulation of physical activity and insulin sensitivity. Thus, the aim of this study was to evaluate the effects of various circuit resistance (CRT) intensities on circulating adropin levels and IR and their relation.
Forty-five voluntarily male men randomly were divided into 5 groups; control and 4 groups of CRT (20%, 40%, 60% and 80% of one-repetition maximum (1-RM)). Training groups performed CRT protocol 3 times a week for 6 weeks. Blood samples were drawn before and 48 h after the last training session and used for analyzing serum levels of adropin, glucose and insulin.
The results showed that varying CRT intensities were associated with adropin elevation in comparison to the control group. Further analysis revealed that plasma adropin is higher in the 20% 1-RM group compared to the 40% 1-RM group. Furthermore, fasting insulin and glucose, as well as IR, were decreased in response to different CRT intensities. In addition, these reductions were significantly correlated with adropin level.
It can be speculated that different CRT intensities improve IR probably via increasing adropin level, and should be considered as an effective training method for diminishing glucose metabolism disorders.
运动诱导的胰岛素抵抗（IR）改善的潜在机制尚不清楚。内脂素是一种多功能肽，在身体活动和胰岛素敏感性调节中起重要作用。因此，本研究旨在评估不同强度循环抗阻训练（CRT）对循环内脂素水平和胰岛素抵抗的影响及其关系。
45名自愿参与的男性被随机分为5组；对照组和4组CRT训练组（分别为一次重复最大值（1-RM）的20%、40%、60%和80%）。训练组每周进行3次CRT训练，共6周。在最后一次训练前和训练后48小时采集血样，用于分析血清内脂素、葡萄糖和胰岛素水平。
结果显示，与对照组相比，不同强度的CRT训练均与内脂素升高有关。进一步分析表明，20% 1-RM组的血浆内脂素水平高于40% 1-RM组。此外，不同强度的CRT训练后空腹胰岛素和葡萄糖水平以及胰岛素抵抗均降低。此外，这些降低与内脂素水平显著相关。
可以推测，不同强度的CRT训练可能通过提高内脂素水平改善胰岛素抵抗，应被视为改善糖代谢紊乱的有效训练方法。
