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“充分缓解疼痛”作为癌症疼痛管理的实用基准:一项关于系列疼痛评分、患者自评疼痛缓解及镇痛药充分性感知的前瞻性研究

'Sufficient Pain relief ' as a Practical Benchmark in Cancer Pain Management: A Prospective Study of Serial Pain Scores, Patient-rated Pain Relief and Perceived Sufficiency of Analgesics.

作者信息

George Reena, Huang Tiffany, Kandasamy Ramu, Siromony Helen Grace, Kothandan Poornima

机构信息

Department of Continuing Medical Education, Christian Medical College, Vellore, Tamil Nadu, India.

Palliative Care Unit, Christian Medical College, Vellore, Tamil Nadu, India.

出版信息

Indian J Palliat Care. 2022 Apr-Jun;28(2):160-166. doi: 10.25259/IJPC_89_21. Epub 2022 Mar 29.

DOI:10.25259/IJPC_89_21
PMID:35673684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9168294/
Abstract

OBJECTIVES

Serial pain scores are used to guide pain management but there can be variability in what constitutes 'adequate' pain relief for an individual patient. We aimed to evaluate how patient-rated sufficiency of pain relief corresponded to pain scores, pain relief scores, and the felt need for increasing analgesics.

MATERIAL AND METHODS

Baseline and follow-up scores on the 11-point numerical rating scale (11-NRS) and verbal rating scale were obtained for116 patients with cancer pain. Patients used the pain relief sufficiency rating (PRSR) to rate pain relief as 'no reduction,' 'some reduction, but not enough,' 'sufficient reduction,' and 'very good reduction.' They also rated analgesics as 'sufficient' or 'insufficient.' Receiver-operating characteristic (ROC) curve analysis was used to compare PRSR responses with follow-up pain scores, patient rated percentage pain relief, and the perceived need for an increase in analgesics.

RESULTS

The 11-NRS had an area under the ROC curve of 94.2% against the PRSR. A pain score of three provided the best cutoff to identify adequate pain relief (88.2% sensitivity and 85.7% specificity). Follow-up verbal pain scores corresponded to PRSR categories (severe pain: no reduction; moderate pain: some reduction; mild pain: sufficient reduction and no pain: very good reduction). The PRSR identified 97.3% of patients who wanted analgesics increased and 85% of those who said pain medications were sufficient.

CONCLUSION

The PRSR is a brief, simple and intuitive measure to elicit patient perceptions on the sufficiency of pain relief. Our findings suggest that it might be a useful tool in pain and symptom management.

摘要

目的

连续疼痛评分用于指导疼痛管理,但对于个体患者而言,“充分”的疼痛缓解标准可能存在差异。我们旨在评估患者对疼痛缓解充分性的评分与疼痛评分、疼痛缓解评分以及增加镇痛药的实际需求之间的对应关系。

材料与方法

对116例癌症疼痛患者进行了11点数字评定量表(11-NRS)和言语评定量表的基线及随访评分。患者使用疼痛缓解充分性评分(PRSR)将疼痛缓解程度评定为“无缓解”“有所缓解,但仍不足”“充分缓解”和“非常好的缓解”。他们还对镇痛药的效果评定为“足够”或“不足”。采用受试者工作特征(ROC)曲线分析,将PRSR的反应与随访疼痛评分、患者自评的疼痛缓解百分比以及增加镇痛药的感知需求进行比较。

结果

11-NRS针对PRSR的ROC曲线下面积为94.2%。疼痛评分为3分时,能最好地界定充分的疼痛缓解(灵敏度为88.2%,特异度为85.7%)。随访言语疼痛评分与PRSR类别相对应(重度疼痛:无缓解;中度疼痛:有所缓解;轻度疼痛:充分缓解;无痛:非常好的缓解)。PRSR识别出97.3%希望增加镇痛药的患者以及85%认为止痛药足够的患者。

结论

PRSR是一种简短、简单且直观的方法,可用于了解患者对疼痛缓解充分性的看法。我们的研究结果表明,它可能是疼痛和症状管理中的一种有用工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/d96fa57cf93f/IJPC-28-160-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/ea6fd2ba117f/IJPC-28-160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/cca8486afe81/IJPC-28-160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/9346aa071ba7/IJPC-28-160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/d96fa57cf93f/IJPC-28-160-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/ea6fd2ba117f/IJPC-28-160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/cca8486afe81/IJPC-28-160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/9346aa071ba7/IJPC-28-160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b806/9168294/d96fa57cf93f/IJPC-28-160-g004.jpg

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