Li Meng-Ting, Xie Long, Jiang Hai-Mei, Huang Qun, Tong Rong-Sheng, Li Xiang, Xie Xin, Liu Hong-Mei
Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy and College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2022 May 23;13:878776. doi: 10.3389/fphar.2022.878776. eCollection 2022.
Licochalcone A (LA), a useful and valuable flavonoid, is isolated from Fisch. ex DC. and widely used clinically in traditional Chinese medicine. We systematically updated the latest information on the pharmacology of LA over the past decade from several authoritative internet databases, including Web of Science, Elsevier, Europe PMC, Wiley Online Library, and PubMed. A combination of keywords containing "Licochalcone A," "Flavonoid," and "Pharmacological Therapy" was used to help ensure a comprehensive review. Collected information demonstrates a wide range of pharmacological properties for LA, including anticancer, anti-inflammatory, antioxidant, antibacterial, anti-parasitic, bone protection, blood glucose and lipid regulation, neuroprotection, and skin protection. LA activity is mediated through several signaling pathways, such as PI3K/Akt/mTOR, P53, NF-κB, and P38. Caspase-3 apoptosis, MAPK inflammatory, and Nrf2 oxidative stress signaling pathways are also involved with multiple therapeutic targets, such as TNF-α, VEGF, Fas, FasL, PI3K, AKT, and caspases. Recent studies mainly focus on the anticancer properties of LA, which suggests that the pharmacology of other aspects of LA will need additional study. At the end of this review, current challenges and future research directions on LA are discussed. This review is divided into three parts based on the pharmacological effects of LA for the convenience of readers. We anticipate that this review will inspire further research.
甘草查尔酮A（LA）是一种有用且有价值的黄酮类化合物，从光果甘草中分离得到，在传统中药中广泛应用于临床。我们通过检索包括Web of Science、Elsevier、Europe PMC、Wiley Online Library和PubMed在内的多个权威网络数据库，系统更新了过去十年中关于LA药理学的最新信息。使用包含“甘草查尔酮A”、“黄酮类化合物”和“药物治疗”的关键词组合，以确保全面综述。收集到的信息表明LA具有广泛的药理特性，包括抗癌、抗炎、抗氧化、抗菌、抗寄生虫、骨骼保护、血糖和血脂调节、神经保护以及皮肤保护。LA的活性通过多种信号通路介导，如PI3K/Akt/mTOR、P53、NF-κB和P38。半胱天冬酶-3凋亡、MAPK炎症和Nrf2氧化应激信号通路也与多个治疗靶点有关，如TNF-α、VEGF、Fas、FasL、PI3K、AKT和半胱天冬酶。最近的研究主要集中在LA的抗癌特性上，这表明LA其他方面的药理学还需要进一步研究。在本综述的结尾，讨论了LA当前面临的挑战和未来的研究方向。为方便读者，本综述根据LA的药理作用分为三个部分。我们预计本综述将激发进一步的研究。
