Continuum (Minneap Minn). 2022 Jun 1;28(3):901-936. doi: 10.1212/CON.0000000000001089.
This article presents a practical approach to the evaluation of patients with rapidly progressive dementia.
The approach presented in this article builds upon the standard dementia evaluation, leveraging widely available tests and emergent specific markers of disease to narrow the differential diagnosis and determine the cause(s) of rapid progressive decline. The discovery of treatment-responsive causes of rapidly progressive dementia underscores the need to determine the cause early in the symptomatic course when treatments are most likely to halt or reverse cognitive decline.
A pragmatic and organized approach to patients with rapidly progressive dementia is essential to mitigate diagnostic and therapeutic challenges and optimize patient outcomes.
本文提出了一种评估快速进展性痴呆患者的实用方法。
本文提出的方法建立在标准痴呆评估的基础上，利用广泛可用的测试和新兴的特定疾病标志物来缩小鉴别诊断范围，并确定快速进行性下降的原因。快速进展性痴呆的治疗反应性病因的发现强调了在症状出现早期确定病因的必要性，因为此时治疗最有可能阻止或逆转认知能力下降。
对于快速进展性痴呆患者，采取务实和有组织的方法对于缓解诊断和治疗挑战以及优化患者预后至关重要。
