帕金森病中的认知障碍和痴呆。

Cognitive Impairment and Dementia in Parkinson Disease.

机构信息

Parkinson's Disease and Movement Disorders, Shirley Ryan AbilityLab, 355 East Erie Street, Chicago, IL 60611, USA; Departments of Physical Medicine and Rehabilitation and Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Chicago, IL 60611, USA.

Neuropsychology, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Chicago, IL 60611, USA; Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Chicago, IL 60611, USA.

出版信息

Clin Geriatr Med. 2020 May;36(2):365-377. doi: 10.1016/j.cger.2020.01.001. Epub 2020 Jan 23.

DOI:10.1016/j.cger.2020.01.001

PMID:32222308

Abstract

In the comprehensive care of people with Parkinson disease (PD), recognition of cognitive impairment is essential. Cognitive impairment in PD can be varied in its clinical features and rates of progression and is now recognized to occur throughout the disease, from early, de novo to more advanced stages. However, the many factors related to the disease itself, underlying pathologies, comorbidities, and genetics may play a role in the development of mild cognitive impairment (PD-MCI) and dementia (PDD). To date, the field lacks curative or disease-modifying treatments for PD cognitive impairment and has few effective, robust symptomatic therapies for PDD or PD-MCI.

摘要

在帕金森病（PD）患者的全面护理中，识别认知障碍至关重要。PD 患者的认知障碍在临床表现和进展速度上可能存在差异，现在已被认识到它可以发生在疾病的各个阶段，从早期、新发至更晚期。然而，与疾病本身、潜在病理、合并症和遗传相关的许多因素可能在轻度认知障碍（PD-MCI）和痴呆（PDD）的发展中发挥作用。迄今为止，该领域缺乏针对 PD 认知障碍的治愈或疾病修饰治疗方法，也几乎没有针对 PDD 或 PD-MCI 的有效、稳健的对症治疗方法。