Kolonel L N, Hankin J H, Yoshizawa C N
Cancer Res. 1987 Jun 1;47(11):2982-5.
Vitamin A intake was assessed from dietary histories on 452 men with prostate cancer and 899 population controls in Hawaii during the period 1977-1983. In the group of men less than 70 years of age, there were no significant associations of this nutrient with risk for prostate cancer. In the men greater than or equal to 70 years, however, risk increased directly with the amount of vitamin A consumed (relative risk of 2.0 for the highest relative to the lowest intake quartile, and a significant linear trend, P less than 0.01). The findings were similar for the various components of vitamin A but were somewhat stronger for total carotenes than for total retinol. These results were generally consistent across the five ethnic groups and were not affected by statistical adjustment for dietary fat. Possible mechanisms for this risk enhancement by vitamin A in elderly men are proposed.
1977年至1983年期间，通过饮食史对夏威夷452名前列腺癌男性患者和899名人群对照者的维生素A摄入量进行了评估。在年龄小于70岁的男性组中，这种营养素与前列腺癌风险之间没有显著关联。然而，在年龄大于或等于70岁的男性中，风险随着维生素A摄入量的增加而直接增加（最高摄入量四分位数相对于最低摄入量四分位数的相对风险为2.0，且有显著的线性趋势，P<0.01）。维生素A各成分的研究结果相似，但总类胡萝卜素的结果比总视黄醇的结果略强。这些结果在五个种族群体中总体一致，且不受饮食脂肪统计调整的影响。文中提出了老年男性中维生素A增加这种风险的可能机制。
