鼓励乌干达坎帕拉少女 HPV 疫苗接种覆盖率的提高。

Encouraging improvement in HPV vaccination coverage among adolescent girls in Kampala, Uganda.

机构信息

Department of Paediatrics & Child Health, Makerere University, Kampala, Uganda.

Administration Department, East Africa Centre for Vaccines and Immunization (ECAVI), Kampala, Uganda.

出版信息

PLoS One. 2022 Jun 9;17(6):e0269655. doi: 10.1371/journal.pone.0269655. eCollection 2022.

DOI:10.1371/journal.pone.0269655

PMID:35679304

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9182299/

Abstract

INTRODUCTION

WHO recommends vaccination against HPV for girls before sexual debut. Uganda started HPV vaccination in 2008 as pilot programs in 2 districts, followed by national roll out in 2015. Despite the availability of vaccines against human papillomavirus (HPV) in Uganda in the period covered by the study, there was reported low HPV vaccine uptake and completion especially of the second dose in Uganda; with little information available on timely completion of HPV vaccine and the associated factors in Uganda. This study was therefore done to determine the HPV vaccine dose 2 completion and describe the possible factors associated with timely HPV vaccine completion and non-completion among girls of age 9-14 years attending the adolescent clinic at Mulago hospital.

METHODS

A retrospective mixed methods study was conducted in Mulago National Referral hospital adolescent clinic. Data were mainly collected through review of charts and folders for clinic attendance by eligible girls and focus group discussions with eligible girls that completed the 2 doses of HPV vaccine on recommended/scheduled time.

RESULTS

Out of the 201 girls studied, 87 girls (43.3%) had timely completion of the HPV vaccination. Knowledge about HPV infection and HPV vaccine benefits, positive peer influence and healthcare worker recommendation to get vaccinated at health facility level positively influenced timely completion of HPV vaccine. Among barriers to completion of HPV vaccine identified were: inadequate information about HPV infection and HPV vaccine, concerns about HPV vaccine efficacy and safety, unclear communication with adolescents/caregivers from healthcare workers and -stock out of the HPV vaccine.

CONCLUSION

Timely completion of the second dose of HPV vaccine among girls attending the adolescent clinic of Mulago hospital was low (at 43.3%) but higher when compared to earlier published reports. Interventions around improved social mobilization, enhanced outreach and static vaccination approach and education of eligible girls on HPV vaccination can help increase vaccine uptake.

摘要

简介

世界卫生组织（WHO）建议在女性初次性行为之前接种 HPV 疫苗。乌干达于 2008 年开始在两个地区试点 HPV 疫苗接种，随后于 2015 年在全国范围内推广。尽管在研究期间乌干达已经有了针对人类乳头瘤病毒（HPV）的疫苗，但据报道，HPV 疫苗接种率较低，特别是第二剂接种率较低；关于乌干达 HPV 疫苗及时接种情况及其相关因素的信息很少。因此，本研究旨在确定 HPV 疫苗第二剂的接种完成情况，并描述与女孩及时完成 HPV 疫苗接种及其不接种相关的可能因素，这些女孩年龄在 9-14 岁，在穆拉戈医院的青少年诊所就诊。

方法

在穆拉戈国家转诊医院的青少年诊所进行了一项回顾性混合方法研究。主要通过查看图表和文件夹中符合条件的女孩就诊记录收集数据，并与按推荐/计划时间完成 HPV 疫苗两剂接种的符合条件的女孩进行焦点小组讨论。

结果

在所研究的 201 名女孩中，有 87 名女孩（43.3%）及时完成了 HPV 疫苗接种。对 HPV 感染和 HPV 疫苗益处的了解、积极的同伴影响以及医护人员建议在医疗机构接种疫苗，这些因素均对及时完成 HPV 疫苗接种产生了积极影响。在确定的 HPV 疫苗接种障碍中，包括：对 HPV 感染和 HPV 疫苗的信息不足、对 HPV 疫苗疗效和安全性的担忧、医护人员与青少年/照顾者之间沟通不清以及 HPV 疫苗缺货。