Stem Cell and Regenerative Medicine Lab, Department of Medical Science Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Cell Rep. 2022 Jun 14;39(11):110955. doi: 10.1016/j.celrep.2022.110955. Epub 2022 May 27.
Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven inflammation is the leading cause of acute cardiac injury associated with coronavirus disease 2019 (COVID-19). However, in-depth knowledge of the injury characteristics of the heart affected by inflammation is lacking. In this study, using a quantitative spatial proteomics strategy that combines comparative anatomy, laser-capture microdissection, and histological examination, we establish a region-resolved proteome map of the myocardia and microvessels with obvious inflammatory cells from hearts of patients with COVID-19. A series of molecular dysfunctions of myocardia and microvessels is observed in different cardiac regions. The myocardia and microvessels of the left atrial are the most susceptible to virus infection and inflammatory storm, suggesting more attention should be paid to the lesion and treatment of these two parts. These results can guide in improving clinical treatments for cardiovascular diseases associated with COVID-19.
由于严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起的炎症导致的直接心肌和血管损伤，是与 2019 年冠状病毒病（COVID-19）相关的急性心脏损伤的主要原因。然而，人们对受炎症影响的心脏损伤特征知之甚少。在这项研究中，我们使用一种定量空间蛋白质组学策略，结合比较解剖学、激光捕获显微切割和组织学检查，建立了 COVID-19 患者心脏中具有明显炎症细胞的心肌和微血管的区域分辨蛋白质组图谱。在不同的心脏区域观察到一系列心肌和微血管的分子功能障碍。左心房的心肌和微血管最容易受到病毒感染和炎症风暴的影响，这表明应该更加注意这两部分的病变和治疗。这些结果可以指导改善与 COVID-19 相关的心血管疾病的临床治疗。
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