Choi Janghan, Tompkins Yuguo Huo, Teng Po-Yun, Gogal Jr Robert M, Kim Woo Kyun
Department of Poultry Science, University of Georgia, Athens, GA 30602, USA.
Department of Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Animals (Basel). 2022 May 27;12(11):1378. doi: 10.3390/ani12111378.
The purpose of this study was to evaluate effects of tannic acid (TA) on growth performance, fecal moisture content, oocyst shedding, gut permeability, lesion score, intestinal morphology, apparent ileal digestibility, and the antioxidant and immune system of broilers infected with Eimeria maxima. A total of 420 one-day-old broilers were distributed to five treatments with seven replicates of 12 birds. The five treatments were the (1) sham-challenged control (SCC; birds fed a control diet and administrated with PBS); (2) challenged control (CC; birds fed a control diet and inoculated with E. maxima); (3) tannic acid 0.5 (TA0.5; CC + 500 mg/kg TA); (4) tannic acid 2.75 (TA2.75; CC + 2750 mg/kg TA); and (5) tannic acid 5 (TA5; CC + 5000 mg/kg TA). The TA2.75 group had significantly lower gut permeability compared to the CC group at 5 days post-infection (dpi). Supplementation of TA linearly reduced oocyst shedding of E. maxima at 7 to 9 dpi (p < 0.05). At 13 dpi, the TA2.75 group had significantly greater apparent ileal digestibility (AID) of dry matter (DM) and organic matter (OM) compared to the CC group. At 13 dpi, supplementation of TA linearly increased jejunal villus height (VH). Thus, this study showed that supplementation of TA at levels of 500 to 2750 mg/kg has the potential to be an anti-coccidial agent against E. maxima in broilers.
本研究的目的是评估单宁酸（TA）对感染巨型艾美耳球虫的肉鸡生长性能、粪便含水量、卵囊排泄、肠道通透性、病变评分、肠道形态、回肠表观消化率以及抗氧化和免疫系统的影响。总共420只1日龄肉鸡被分为5个处理组，每组7个重复，每个重复12只鸡。这5个处理组分别为：（1）假感染对照组（SCC；鸡饲喂对照日粮并给予磷酸盐缓冲液）；（2）感染对照组（CC；鸡饲喂对照日粮并接种巨型艾美耳球虫）；（3）单宁酸0.5组（TA0.5；CC + 500 mg/kg TA）；（4）单宁酸2.75组（TA2.75；CC + 2750 mg/kg TA）；（5）单宁酸5组（TA5；CC + 5000 mg/kg TA）。感染后5天（dpi）时，TA2.75组的肠道通透性显著低于CC组。在7至9 dpi时，添加TA可使巨型艾美耳球虫的卵囊排泄呈线性减少（p < 0.05）。在13 dpi时，TA2.75组的干物质（DM）和有机物（OM）的回肠表观消化率（AID）显著高于CC组。在13 dpi时，添加TA可使空肠绒毛高度（VH）呈线性增加。因此，本研究表明，添加500至2750 mg/kg的TA有可能成为肉鸡抗巨型艾美耳球虫的抗球虫剂。
