Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Int J Mol Sci. 2022 May 31;23(11):6204. doi: 10.3390/ijms23116204.
The liquid-liquid phase separation (LLPS) of biomolecules is a phenomenon which is nowadays recognized as the driving force for the biogenesis of numerous functional membraneless organelles and cellular bodies. The interplay between the protein primary sequence and phase separation remains poorly understood, despite intensive research. To uncover the sequence-encoded signals of protein capable of undergoing LLPS, we developed a novel web platform named BIAPSS (Bioinformatics Analysis of LLPS Sequences). This web server provides on-the-fly analysis, visualization, and interpretation of the physicochemical and structural features for the superset of curated LLPS proteins.
液液相分离 (LLPS) 是生物分子的一种现象，如今被认为是众多功能性无膜细胞器和细胞体生物发生的驱动力。尽管进行了深入的研究，但蛋白质一级序列和相分离之间的相互作用仍知之甚少。为了揭示能够进行 LLPS 的蛋白质的序列编码信号，我们开发了一个名为 BIAPSS（LLPS 序列的生物信息学分析）的新型网络平台。该网络服务器提供即时分析、可视化和解释超集的 curated LLPS 蛋白质的物理化学和结构特征。
