Ansari Shamshul, Yamaoka Yoshio
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Oita, Japan.
Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX 77030, USA.
J Clin Med. 2022 May 31;11(11):3141. doi: 10.3390/jcm11113141.
colonize the gastric mucosa of at least half of the world's population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of -associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of infection animal models.
定植于世界上至少一半人口的胃黏膜。持续感染与胃炎、消化性溃疡疾病的发生以及胃癌和胃黏膜相关淋巴组织（MALT）淋巴瘤风险增加有关。使用多种动物模型的体内研究为理解相关并发症的病理生理学提供了关键证据。许多动物模型，如蒙古沙鼠、转基因小鼠模型、豚鼠以及包括非人灵长类动物在内的其他动物，因其在引发胃部并发症方面的持续关联而被广泛使用。然而，寻找适合体内实验以理解胃癌和MALT淋巴瘤病理生理学的动物模型是一项复杂的任务。在本综述中，我们总结了科学文献中最合适和最新的信息，以了解感染动物模型的作用和重要性。
