动物模型与感染
Animal Models and Infection.
作者信息
Ansari Shamshul, Yamaoka Yoshio
机构信息
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Oita, Japan.
Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
J Clin Med. 2022 May 31;11(11):3141. doi: 10.3390/jcm11113141.
Abstract
colonize the gastric mucosa of at least half of the world's population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of -associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of infection animal models.
摘要
定植于世界上至少一半人口的胃黏膜。持续感染与胃炎、消化性溃疡疾病的发生以及胃癌和胃黏膜相关淋巴组织（MALT）淋巴瘤风险增加有关。使用多种动物模型的体内研究为理解相关并发症的病理生理学提供了关键证据。许多动物模型，如蒙古沙鼠、转基因小鼠模型、豚鼠以及包括非人灵长类动物在内的其他动物，因其在引发胃部并发症方面的持续关联而被广泛使用。然而，寻找适合体内实验以理解胃癌和MALT淋巴瘤病理生理学的动物模型是一项复杂的任务。在本综述中，我们总结了科学文献中最合适和最新的信息，以了解感染动物模型的作用和重要性。
相似文献
1
Animal Models and Infection.动物模型与感染
J Clin Med. 2022 May 31;11(11):3141. doi: 10.3390/jcm11113141.
2
Association of Helicobacter pylori with gastroduodenal diseases.幽门螺杆菌与胃十二指肠疾病的关联。
Jpn J Infect Dis. 1999 Oct;52(5):183-97.
3
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].[幽门螺杆菌感染蒙古沙鼠胃黏膜病理变化的药理学研究]
Nihon Yakurigaku Zasshi. 2001 Oct;118(4):259-68. doi: 10.1254/fpj.118.259.
4
5
Ethanol intake preceding Helicobacter pylori inoculation promotes gastric mucosal inflammation in Mongolian gerbils.在蒙古沙鼠中，幽门螺杆菌接种前摄入乙醇会促进胃黏膜炎症。
J Gastroenterol Hepatol. 1999 Nov;14(11):1062-9. doi: 10.1046/j.1440-1746.1999.01999.x.
6
Development of gastric adenocarcinoma in Mongolian gerbils after long-term infection with Helicobacter pylori.幽门螺杆菌长期感染后蒙古沙鼠胃腺癌的发生
J Gastroenterol Hepatol. 2004 Oct;19(10):1192-8. doi: 10.1111/j.1440-1746.2004.03469.x.
7
8
Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice.幽门螺杆菌感染本身会导致胃癌或十二指肠溃疡吗？在蒙古沙鼠和近交系小鼠中的证据不足。
FEMS Immunol Med Microbiol. 2007 Jul;50(2):184-9. doi: 10.1111/j.1574-695X.2007.00249.x.
9
[Rodent models of Helicobacter pylori infection and their utility].[幽门螺杆菌感染的啮齿动物模型及其应用]
Nihon Yakurigaku Zasshi. 1998 May;111(5):289-96. doi: 10.1254/fpj.111.289.
10
Helicobacter suis infection is associated with nodular gastritis-like appearance of gastric mucosa-associated lymphoid tissue lymphoma.猪幽门螺杆菌感染与黏膜相关淋巴组织淋巴瘤的结节状胃炎样外观有关。
Cancer Med. 2019 Aug;8(9):4370-4379. doi: 10.1002/cam4.2314. Epub 2019 Jun 18.
引用本文的文献
1
Co-Infection Dynamics of and Helminths: A Double-Edged Sword.与蠕虫的共同感染动态：一把双刃剑。 （你提供的原文中“Co-Infection Dynamics of and Helminths”存在信息缺失，推测完整原文可能是“Co-Infection Dynamics of Viruses and Helminths”，这里是按照推测完整后的内容翻译的，你可根据实际情况调整。）
Int J Mol Sci. 2025 Aug 19;26(16):8001. doi: 10.3390/ijms26168001.
2
Precancerous pathways to gastric cancer: a review of experimental animal models recapitulating the correa cascade.胃癌的癌前病变途径：对重现科雷亚级联反应的实验动物模型的综述
Front Cell Dev Biol. 2025 Jul 2;13:1620756. doi: 10.3389/fcell.2025.1620756. eCollection 2025.
3
Standardized aqueous extract of Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer in rats.药用植物的标准化水提取物可改善大鼠因盐酸/乙醇诱导的胃溃疡所产生的氧化应激和炎症反应。
Front Pharmacol. 2025 Jun 18;16:1599810. doi: 10.3389/fphar.2025.1599810. eCollection 2025.
4
A critical review on and models for the investigation of infection.关于感染调查的[具体内容]和模型的批判性综述。 （原文中“and”前后内容缺失，翻译可能不太准确，完整准确翻译需补充完整原文信息）
Front Cell Infect Microbiol. 2025 May 14;15:1516237. doi: 10.3389/fcimb.2025.1516237. eCollection 2025.
5
A unique strain to study gastric cancer development.一种用于研究胃癌发展的独特菌株。
Microbiol Spectr. 2025 Jan 7;13(1):e0216324. doi: 10.1128/spectrum.02163-24. Epub 2024 Dec 6.
6
Developing a potent vaccine against : critical considerations and challenges.开发针对……的有效疫苗：关键考量与挑战
Expert Rev Mol Med. 2024 Nov 25;27:e12. doi: 10.1017/erm.2024.19.
7
The toxic effects of and benzo(a)pyrene in inducing atrophic gastritis and gut microbiota dysbiosis in Mongolian gerbils.[物质名称]和苯并(a)芘对蒙古沙鼠诱导萎缩性胃炎和肠道微生物群失调的毒性作用。 （你原文中“and”前面缺少具体物质名称，我先按此形式翻译，你可补充完整后再看）
Food Sci Nutr. 2024 Jul 29;12(10):7568-7580. doi: 10.1002/fsn3.4368. eCollection 2024 Oct.
8
Association between Helicobacter pylori infection and type 2 diabetes mellitus: a retrospective cohort study and bioinformatics analysis.幽门螺杆菌感染与 2 型糖尿病的关系：一项回顾性队列研究和生物信息学分析。
BMC Endocr Disord. 2024 Aug 30;24(1):168. doi: 10.1186/s12902-024-01694-2.
9
The Helicobacter pylori infection alters the intercellular junctions on the pancreas of gerbils (Meriones unguiculatus).幽门螺杆菌感染改变沙鼠（黑线毛足鼠）胰腺的细胞间连接。
World J Microbiol Biotechnol. 2024 Jul 20;40(9):273. doi: 10.1007/s11274-024-04081-0.
10
Outer membrane vesicles from genetically engineered serovar Typhimurium presenting antigens UreB and CagA induce protection against infection in mice.携带抗原 UreB 和 CagA 的基因工程鼠伤寒血清型 Typhimurium 外膜囊泡诱导小鼠抗感染保护。
Virulence. 2024 Dec;15(1):2367783. doi: 10.1080/21505594.2024.2367783. Epub 2024 Jun 27.
本文引用的文献
1
CD4 CD8αα T cells in the gastric epithelium mediate chronic inflammation induced by Helicobacter felis.胃上皮中的 CD4 CD8αα T 细胞介导幽门螺杆菌感染引起的慢性炎症。
Microb Pathog. 2021 Oct;159:105151. doi: 10.1016/j.micpath.2021.105151. Epub 2021 Aug 24.
2
Pepsinogen and Serum IgG Detection Is a Valuable Diagnostic Method for Infection in a Low-Prevalence Country: A Report from Sri Lanka.胃蛋白酶原和血清IgG检测是低流行率国家感染的一种有价值的诊断方法：来自斯里兰卡的报告。
Diagnostics (Basel). 2021 Jul 29;11(8):1364. doi: 10.3390/diagnostics11081364.
3
Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis.程序性死亡配体 1 表达的经典树突状细胞减轻幽门螺杆菌诱导的胃炎。
Cell Mol Gastroenterol Hepatol. 2021;12(2):715-739. doi: 10.1016/j.jcmgh.2021.04.007. Epub 2021 Apr 21.
4
In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori.体内激活 pH 响应氧化酶样石墨纳米酶用于选择性杀灭幽门螺杆菌。
Nat Commun. 2021 Mar 31;12(1):2002. doi: 10.1038/s41467-021-22286-x.
5
A Mouse Model of Helicobacter pylori Infection.幽门螺杆菌感染的小鼠模型。
Methods Mol Biol. 2021;2283:131-151. doi: 10.1007/978-1-0716-1302-3_14.
6
Amoxicillin and Clarithromycin Mucoadhesive Delivery System for Infection in a Mouse Model: Characterization, Pharmacokinetics, and Efficacy.用于小鼠模型感染的阿莫西林和克拉霉素黏膜黏附递送系统：表征、药代动力学及疗效
Pharmaceutics. 2021 Jan 24;13(2):153. doi: 10.3390/pharmaceutics13020153.
7
Microbiome Signatures in a Fast- and Slow-Progressing Gastric Cancer Murine Model and Their Contribution to Gastric Carcinogenesis.快速进展型和缓慢进展型胃癌小鼠模型中的微生物组特征及其对胃癌发生的作用
Microorganisms. 2021 Jan 17;9(1):189. doi: 10.3390/microorganisms9010189.
8
Sustained infection accelerates gastric dysplasia in a mouse model.持续感染加速了小鼠模型中的胃发育异常。
Life Sci Alliance. 2020 Dec 11;4(2). doi: 10.26508/lsa.202000967. Print 2021 Feb.
9
Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis.二羰基亲电子试剂介导炎症诱导的胃肠道癌变。
Gastroenterology. 2021 Mar;160(4):1256-1268.e9. doi: 10.1053/j.gastro.2020.11.006. Epub 2020 Nov 13.
10
PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice.PD-1 信号促进肿瘤浸润性髓系来源的抑制细胞和小鼠胃肿瘤发生。
Gastroenterology. 2021 Feb;160(3):781-796. doi: 10.1053/j.gastro.2020.10.036. Epub 2020 Oct 29.
Zotero 插件