Department of Orthopedics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 81267, Taiwan.
Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Nutrients. 2022 May 26;14(11):2206. doi: 10.3390/nu14112206.
In this paper, we aimed to examine the protective role of hyperuricemia in the prevalence of osteoporosis in a large Asian cohort. A total of 119,037 participants from 29 recruitment centers in Taiwan were enrolled onto our study. Participants with serum uric acid greater than 7.0 mg/dL in men and 6.0 mg/dL in women were classified as the hyperuricemia group whereas the others were the control group. The mean age of all participants was 50; there were 23,114 subjects (19%) with hyperuricemia. Osteoporosis was observed in 8243 (9%) and 1871 (8%) participants in the control and hyperuricemia groups, respectively. After adjusting for confounders, a lower risk of osteoporosis was found in the hyperuricemia group compared with the control group (odds ratio, 0.916; 95% confidence interval, 0.864 to 0.970). A subgroup analysis showed that hyperuricemia was associated with a lower risk of osteoporosis in females, but not in males. Women with serum uric acid greater than 8.0 mg/dL were not associated with a greater risk of osteoporosis. Our study suggests that hyperuricemia decreases the risk of osteoporosis in females, but not in males. The protective role was no longer apparent when the serum uric acid level was greater than 8 mg/dL.
在这项研究中，我们旨在探讨高尿酸血症在亚洲大队列人群骨质疏松症发病中的保护作用。共纳入了来自台湾 29 个招募中心的 119037 名参与者。男性血清尿酸水平大于 7.0mg/dL 和女性大于 6.0mg/dL 的参与者被归类为高尿酸血症组，而其他参与者则为对照组。所有参与者的平均年龄为 50 岁；23114 名（19%）参与者患有高尿酸血症。对照组和高尿酸血症组分别有 8243 名（9%）和 1871 名（8%）参与者患有骨质疏松症。在校正了混杂因素后，与对照组相比，高尿酸血症组发生骨质疏松症的风险较低（比值比，0.916；95%置信区间，0.864 至 0.970）。亚组分析显示，高尿酸血症与女性而非男性骨质疏松症风险降低相关。血清尿酸水平大于 8.0mg/dL 的女性与骨质疏松症风险增加无关。我们的研究表明，高尿酸血症降低了女性而非男性的骨质疏松症风险。当血清尿酸水平大于 8mg/dL 时，这种保护作用不再明显。
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