Digital Health, Oncology R&D, AstraZeneca, Gaithersburg, MD 20878, USA.
Department of Computer Science, Dartmouth College, Hanover, NH 03755, USA.
Sensors (Basel). 2022 May 24;22(11):3989. doi: 10.3390/s22113989.
Physical activity (PA) is globally recognized as a pillar of general health. Step count, as one measure of PA, is a well known predictor of long-term morbidity and mortality. Despite its popularity in consumer devices, a lack of methodological standards and clinical validation remains a major impediment to step count being accepted as a valid clinical endpoint. Previous works have mainly focused on device-specific step-count algorithms and often employ sensor modalities that may not be widely available. This may limit step-count suitability in clinical scenarios. In this paper, we trained neural network models on publicly available data and tested on an independent cohort using two approaches: generalization and personalization. Specifically, we trained neural networks on accelerometer signals from one device and either directly applied them or adapted them individually to accelerometer data obtained from a separate subject cohort wearing multiple distinct devices. The best models exhibited highly accurate step-count estimates for both the generalization (96-99%) and personalization (98-99%) approaches. The results demonstrate that it is possible to develop device-agnostic, accelerometer-only algorithms that provide highly accurate step counts, positioning step count as a reliable mobility endpoint and a strong candidate for clinical validation.
身体活动(PA)在全球范围内被公认为一般健康的支柱。步数作为身体活动的一种衡量标准,是长期发病率和死亡率的一个重要预测指标。尽管在消费类设备中很受欢迎,但缺乏方法学标准和临床验证仍然是步数被接受为有效临床终点的主要障碍。以前的工作主要集中在特定于设备的步数算法上,并且经常使用可能无法广泛使用的传感器模式。这可能会限制在临床情况下的步数适用性。在本文中,我们使用两种方法(泛化和个性化)在公开可用的数据上训练神经网络模型,并在独立队列上进行测试:泛化和个性化。具体来说,我们使用一个设备的加速度计信号训练神经网络,然后直接将它们应用于或根据需要对来自佩戴多个不同设备的单独队列的加速度计数据进行单独适配。最佳模型在泛化(96-99%)和个性化(98-99%)方法中都表现出了非常准确的步数估计。结果表明,开发出不依赖于设备的、仅使用加速度计的算法来提供高度准确的步数是可行的,这将步数定位为可靠的移动性终点,并成为临床验证的有力候选者。