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抗菌成骨多功能牙种植体表面的研究进展与展望

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface.

作者信息

Wang Zixuan, Li Baosheng, Cai Qing, Li Xiaoyu, Yin Zhaoyi, Li Birong, Li Zhen, Meng Weiyan

机构信息

Department of Dental Implantology, Hospital of Stomatology, Jilin University, Changchun, China.

Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Changchun, China.

出版信息

Front Bioeng Biotechnol. 2022 May 24;10:921338. doi: 10.3389/fbioe.2022.921338. eCollection 2022.

Abstract

In recent years, dental implantation has become the preferred protocol for restoring dentition defects. Being the direct contact between implant and bone interface, osseointegration is the basis for implant exerting physiological functions. Nevertheless, biological complications such as insufficient bone volume, poor osseointegration, and postoperative infection can lead to implant failure. Emerging antibacterial-osteogenic multifunctional implant surfaces were designed to make up for these shortcomings both during the stage of forming osseointegration and in the long term of supporting the superstructure. In this mini-review, we summarized the recent antibacterial-osteogenic modifications of the dental implant surface. The effects of these modifications on biological performance like soft tissue integration, bone osteogenesis, and immune response were discussed. In addition, the clinical findings and prospects of emerging antibacterial-osteogenic implant materials were also discussed.

摘要

近年来,牙种植已成为修复牙列缺损的首选方案。骨结合作为种植体与骨界面之间的直接接触,是种植体发挥生理功能的基础。然而,诸如骨量不足、骨结合不良和术后感染等生物学并发症可导致种植失败。新型抗菌成骨多功能种植体表面的设计旨在在形成骨结合阶段及长期支持上部结构过程中弥补这些不足。在本综述中,我们总结了牙种植体表面近期的抗菌成骨修饰。讨论了这些修饰对软组织整合、骨生成和免疫反应等生物学性能的影响。此外,还讨论了新型抗菌成骨种植材料的临床研究结果及前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07c1/9171039/285d53601907/fbioe-10-921338-g001.jpg

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