Sun Yan, Zhang Yu, Zhang Kai, Nan Jiangyu, Xiong Zixuan, Liu Wenbin, Hu Yihe, Lei Pengfei
Department of Orthopedics, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
Department of Orthopedic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
J Nanobiotechnology. 2025 Aug 4;23(1):552. doi: 10.1186/s12951-025-03610-9.
Infection and poor osseointegration following orthopedic implantation remain significant challenges that can lead to complications, including prosthesis loosening, delayed fracture healing, and even implant failure. Porous tantalum is a game changer in the field of bone implants. In this study, we employed magnetron sputtering technology to modify ZnO particles on the surface of tantalum nanotubes (TaNTs) in porous tantalum, which were mechanochemically reprogrammed to enhance their properties. This approach enabled functionalization without altering the surface microstructure, resulting in the development of a ZnO-modified tantalum nanotube array coating (TaNTs@ZnO) designed to address infection. ZnO coating, applied via magnetron sputtering, exhibits pH-responsive Zn release and antibacterial activity, achieving over 99% inhibition against S. aureus and E. coli by disrupting bacterial membranes and metabolism. Additionally, TaNTs promote bone marrow mesenchymal stem cells (BMSCs) adhesion and osteogenic differentiation, accelerating bone healing and osseointegration in both femoral condyle and infective bone defect models. In conclusion, TaNTs@ZnO show strong antibacterial and osteogenic capabilities, offering a promising solution for bone defect treatment and infection prevention.
骨科植入后感染和骨整合不良仍然是重大挑战，可能导致包括假体松动、骨折愈合延迟甚至植入失败等并发症。多孔钽是骨植入领域的变革者。在本研究中，我们采用磁控溅射技术在多孔钽中的钽纳米管（TaNTs）表面修饰ZnO颗粒，对其进行机械化学重编程以增强其性能。这种方法能够在不改变表面微观结构的情况下实现功能化，从而开发出一种旨在解决感染问题的ZnO修饰钽纳米管阵列涂层（TaNTs@ZnO）。通过磁控溅射施加的ZnO涂层具有pH响应性的锌释放和抗菌活性，通过破坏细菌膜和代谢对金黄色葡萄球菌和大肠杆菌的抑制率超过99%。此外，TaNTs促进骨髓间充质干细胞（BMSCs）黏附和成骨分化，在股骨髁和感染性骨缺损模型中加速骨愈合和骨整合。总之，TaNTs@ZnO具有强大的抗菌和成骨能力，为骨缺损治疗和感染预防提供了一种有前景的解决方案。
