State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Department of Oral Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Oral Dis. 2023 Nov;29(8):3337-3345. doi: 10.1111/odi.14273. Epub 2022 Jun 23.
To design an improved oral lichen planus (OLP) scoring system, which can be widely applied.
A new scoring system that took reticulation, hyperemia and ulceration (RHU) into account, named as RHU scoring system, was designed for OLP patients' management. The patients were also scored for the reticulation/erythema/ulcer (REU) scoring system, physician global assessment (PGA), numerical rating scale (NRS) and Oral Health Impact Profile-14 (OHIP-14). The reliability and validity analyses were utilized to assess the RHU scoring system. We further applied the RHU scoring system to examine the treatment outcomes of topical dexamethasone sodium phosphate and general hydroxychloroquine hydrochloride among OLP patients.
Forty-eight OLP patients from two medical centers were recruited. This new scoring system has reliability with an internal consistency index Cronbach α 0.49. The Pearson correlation of RHU score with PGA and REU score were 0.891 and 0.675 (p < 0.05) respectively, reflecting satisfactory standard validity. A 10% change in RHU score was used as the disease condition evaluation standard, reflecting satisfactory discriminating validity (t = -5.821, p < 0.001). During follow-ups, scores of all scales decreased at each re-visit. The drop between each visit of OHIP-14 fluctuated compared with the RHU system and NRS.
As a semi-quantitative score system, the RHU scoring system can reflect the severity of OLP patients with hyperemia and ulceration lesions more accurately and sensitively compared with other score systems, which provides the potential to be widely used.
设计一种改良的口腔扁平苔藓（OLP）评分系统，使其能够广泛应用。
为了 OLP 患者的管理，我们设计了一种新的评分系统，该系统考虑了网状、充血和溃疡（RHU），命名为 RHU 评分系统。还对网状/红斑/溃疡（REU）评分系统、医师总体评估（PGA）、数字评分量表（NRS）和口腔健康影响量表-14（OHIP-14）对患者进行评分。采用可靠性和有效性分析来评估 RHU 评分系统。我们进一步应用 RHU 评分系统来检查局部地塞米松磷酸钠和一般羟氯喹盐酸盐治疗 OLP 患者的治疗效果。
从两个医学中心招募了 48 名 OLP 患者。这种新的评分系统具有可靠性，内部一致性指数 Cronbach α 为 0.49。RHU 评分与 PGA 和 REU 评分的 Pearson 相关系数分别为 0.891 和 0.675（p<0.05），反映了满意的标准有效性。10%的 RHU 评分变化被用作疾病状况评估标准，反映了令人满意的区分有效性（t=-5.821，p<0.001）。在随访期间，每个就诊时所有量表的评分都降低了。与 RHU 系统和 NRS 相比，OHIP-14 在每次就诊之间的下降幅度波动较大。
作为一种半定量评分系统，与其他评分系统相比，RHU 评分系统能更准确、更敏感地反映充血和溃疡病变的 OLP 患者的严重程度，这为其广泛应用提供了潜力。
