Kamal Arif Mohd, Sakorikar Tushar, Pal Uttam M, Pandya Hardik J
IEEE Rev Biomed Eng. 2023;16:687-705. doi: 10.1109/RBME.2022.3181700. Epub 2023 Jan 5.
Breast cancer is a leading cause of mortality among women. The patient's survival rate is uncertain due to the limitations in the accuracy of diagnosis and effective monitoring during cancer treatment. The key to efficaciously controlling cancer on a larger scale is effective diagnosis at an early stage of cancer by distinguishing the vital signatures of the diseased from the normal breast tissue. The breast tissue is a heterogeneous turbid media that exhibits multifaceted bulk tissue properties. Various sensing modalities can yield distinct tissue behavior for cancer and adjacent normal tissues, serving as a basis for cancer diagnosis. A novel multimodal diagnostic tool that can concurrently assess the optical, electrical, and mechanical bulk tissue properties can substantially augment the clinical findings such as histopathology, potentially aiding the clinician to establish an accurate and rapid diagnosis of cancer. This review aims to discuss the clinical and engineering aspects along with the unmet challenges of these physical sensing modalities, primarily in the field of optical, electrical, and mechanical. The challenges of combining two or more of these sensing modalities that can significantly enhance the effectiveness of the clinical diagnostic tools are further investigated.
乳腺癌是女性死亡的主要原因之一。由于癌症治疗期间诊断准确性和有效监测存在局限性，患者的生存率尚不确定。在更大范围内有效控制癌症的关键是通过区分患病组织与正常乳腺组织的重要特征，在癌症早期进行有效诊断。乳腺组织是一种异质混浊介质，具有多方面的整体组织特性。各种传感方式可以产生癌症组织和相邻正常组织不同的组织行为，作为癌症诊断的基础。一种能够同时评估光学、电学和力学整体组织特性的新型多模态诊断工具，可以极大地增强诸如组织病理学等临床检查结果，有可能帮助临床医生准确快速地诊断癌症。本综述旨在讨论这些物理传感方式在临床和工程方面以及尚未解决的挑战，主要涉及光学、电学和力学领域。进一步研究了结合两种或更多种这些传感方式所面临的挑战，这些挑战能够显著提高临床诊断工具的有效性。
