Faculty of Kinesiology and Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK, S4S 0A2, Canada,
Endocrine. 2014 Apr;45(3):354-61. doi: 10.1007/s12020-013-0070-4. Epub 2013 Nov 5.
Sarcopenia refers to the progressive loss of muscle mass and muscle function and is a contributing factor for cachexia, bone loss, and frailty. Resistance training produces several physiological adaptations which improve aging musculoskeletal health, such as increased muscle and bone mass and strength. The combination of creatine supplementation and resistance training may further lead to greater physiological benefits. We performed meta-analyses which indicate creatine supplementation combined with resistance training has a positive effect on aging muscle mass and upper body strength compared to resistance training alone. Creatine also shows promise for improving bone mineral density and indices of bone biology. The combination of creatine supplementation and resistance training could be an effective intervention to improve aging musculoskeletal health.
肌肉减少症是指肌肉质量和肌肉功能的进行性丧失，是导致恶病质、骨丢失和虚弱的一个因素。抗阻训练会产生多种生理适应性变化，从而改善衰老的肌肉骨骼健康，如增加肌肉和骨量以及力量。肌酸补充和抗阻训练的结合可能会带来更大的生理益处。我们进行的荟萃分析表明，与单独进行抗阻训练相比，肌酸补充结合抗阻训练对衰老肌肉质量和上半身力量有积极影响。肌酸也有望改善骨矿物质密度和骨生物学指标。肌酸补充和抗阻训练的结合可能是改善衰老肌肉骨骼健康的有效干预措施。
