McIntyre Roger S, Ismail Zahinoor, Watling Christopher P, Weiss Catherine, Meehan Stine R, Musingarimi Primrose, Thase Michael E
Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, 399 Bathurst Street, MP 9-325, Toronto, ON, M5T 2S8, Canada.
Departments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada.
J Patient Rep Outcomes. 2022 Jun 10;6(1):62. doi: 10.1186/s41687-022-00468-5.
Life engagement in the context of mental health is a broad term that describes positive health aspects relating to cognition, vitality, motivation and reward, and the ability to feel pleasure-concepts that are meaningful to patients. The aim of this systematic literature review was to identify validated patient-reported outcomes (PROs) that can assess any aspect of life engagement in adults, in the field of general mental health.
This was a systematic literature review of articles in English from the MEDLINE database (date of search: September 9, 2020). The search strategy had three components: (1) terms to capture PROs; (2) terms to capture mental health; and (3) terms to capture aspects of life engagement. Articles were eligible if they included a PRO that: (1) is named; (2) can be used across mental health disorders; (3) is used to assess any aspect of life engagement; and (4) has undergone psychometric validation and/or qualitative content validation. A list of PROs was extracted.
A total of 1585 records were screened and 233 articles were eligible for inclusion. Within these 233 articles, 49 distinct PROs were identified, two of which specifically captured their authors' interpretation of life engagement: the Engaged Living Scale (ELS) and the Life Engagement Test (LET). However, while the ELS and LET covered motivation and reward, life fulfillment, and value-based living, neither scale captured the cognitive or vitality aspects of life engagement. The remaining identified PROs generally captured single aspects of life engagement, most commonly motivation/reward/energy-apathy, pleasure-anhedonia, and mental/psychological well-being.
Numerous PROs are available that may capture aspects of life engagement. However, a need remains for a new PRO that can be used in clinical trials to provide a more comprehensive description of the improvements in life engagement that patients with mental health disorders may experience with successful treatment.
心理健康背景下的生活参与是一个广义术语，描述了与认知、活力、动机和奖赏以及感受愉悦能力相关的积极健康方面，这些概念对患者具有重要意义。本系统文献综述的目的是确定经过验证的患者报告结局（PROs），这些结局能够评估普通心理健康领域中成年人生活参与的任何方面。
这是一项对MEDLINE数据库中英文文章的系统文献综述（检索日期：2020年9月9日）。检索策略包含三个部分：（1）用于捕捉PROs的术语；（2）用于捕捉心理健康的术语；（3）用于捕捉生活参与方面的术语。如果文章包含以下PRO，则符合入选标准：（1）有名称；（2）可用于各种心理健康障碍；（3）用于评估生活参与的任何方面；（4）经过心理测量学验证和/或定性内容验证。提取了PROs列表。
共筛选了1585条记录，233篇文章符合纳入标准。在这233篇文章中，确定了49个不同的PROs，其中两个特别体现了其作者对生活参与的诠释：参与生活量表（ELS）和生活参与测试（LET）。然而，虽然ELS和LET涵盖了动机和奖赏、生活满意度以及基于价值观的生活，但这两个量表都未涵盖生活参与的认知或活力方面。其余确定的PROs通常只捕捉生活参与的单一方面，最常见的是动机/奖赏/精力 - 冷漠、愉悦 - 快感缺乏以及心理/心理健康。
有许多PROs可用于捕捉生活参与的各个方面。然而，仍然需要一种新的PRO，可用于临床试验，以更全面地描述心理健康障碍患者在成功治疗后生活参与方面可能出现的改善情况。
