Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
ADSI-Austrian Drug Screening Institute GmbH, Innsbruck, Austria.
J Sci Food Agric. 2022 Dec;102(15):7030-7038. doi: 10.1002/jsfa.12064. Epub 2022 Jul 11.
Caragana ambigua has been the part of the dietary routines of the regional people in south-west Pakistan and has traditionally been used for the treatment of diabetes there. There is an increased production of reactive oxygen species in diabetics, leading to gastrointestinal disorders. Natural antioxidants exhibit gastroprotective effects owing to their free-radical scavenging action. C. ambigua possesses appreciable phenolic and flavonoid content; thus, it has the potential to protect against gastrointestinal disorders (e.g. gastric ulcer).
This study reports the anti-ulcer potential of C. ambigua. Four different fractions (chloroform, ethyl acetate, butanol, and aqueous) of plant were compared against omeprazole. Ulcer index, ulcer inhibition percentage, gastric pH and volume, total acidity, gastric protein, gastric wall mucus, and histopathology of gastric walls of rats were assessed. All fractions exhibited a reduction in ulcer index and promotion of percentage of ulcer inhibition compared with the ulcer control group. Furthermore, the fractions revealed a significant (P < 0.001) diminution in gastric volume and total acidity with an increase in pH. Among the fractions investigated, the chloroform fraction unveiled the most promising anti-ulcer activity, which is comparable to omeprazole. Liquid chromatography-tandem mass spectrometry screening of fractions revealed the presence of formononetin and biochanin A (isoflavones reported to have anti-ulcer properties) in the chloroform fraction.
This study establishes that C. ambigua possesses significant potential in reducing gastric ulcer progression. Formononetin and biochanin A are chiefly responsible for the stated bioactivity due to the fact that these compounds were solely present in the chloroform fraction. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
在巴基斯坦西南部，骆驼蓬已成为当地居民饮食的一部分，且传统上被用于治疗糖尿病。糖尿病患者体内会产生大量的活性氧物种，导致胃肠道紊乱。天然抗氧化剂因其自由基清除作用而具有胃保护作用。骆驼蓬含有可观的酚类和类黄酮含量；因此，它具有预防胃肠道疾病（如胃溃疡）的潜力。
本研究报告了骆驼蓬的抗溃疡潜力。将植物的四种不同馏分（氯仿、乙酸乙酯、正丁醇和水）与奥美拉唑进行了比较。评估了大鼠的溃疡指数、溃疡抑制率、胃 pH 值和体积、总酸度、胃蛋白、胃壁黏液和胃壁组织病理学。与溃疡对照组相比，所有馏分均降低了溃疡指数，促进了溃疡抑制率。此外，这些馏分显著（P < 0.001）降低了胃体积和总酸度，增加了 pH 值。在所研究的馏分中，氯仿馏分表现出最有希望的抗溃疡活性，可与奥美拉唑相媲美。馏分的液相色谱-串联质谱筛选表明，氯仿馏分中存在芒柄花素和大豆苷元（具有抗溃疡特性的异黄酮）。
本研究表明骆驼蓬具有显著降低胃溃疡进展的潜力。芒柄花素和大豆苷元主要负责所述的生物活性，因为这些化合物仅存在于氯仿馏分中。© 2022 作者。《食品科学杂志》由 John Wiley & Sons Ltd 代表化学工业协会出版。
