Department of Bioengineering, Faculty of Engineering, Integral University, Lucknow - 226026, UP, India.
Novel Global Community Educational Foundation, Hebersham, NSW2770, Australia.
Curr Med Chem. 2023;30(3):271-285. doi: 10.2174/0929867329666220610090405.
Even though the battle against one of the deadliest diseases, cancer, has advanced remarkably in the last few decades and the survival rate has improved significantly; the search for an ultimate cure remains a utopia. Nanoinformatics, which is bioinformatics coupled with nanotechnology, endows many novel research opportunities in the preclinical and clinical development of personalized nanosized drug carriers in cancer therapy. Personalized nanomedicines serve as a promising treatment option for cancer owing to their noninvasiveness and their novel approach. Explicitly, the field of personalized medicine is expected to have an enormous impact soon because of its many advantages, namely its versatility to adapt a drug to a cohort of patients.
The current review explains the application of this newly emerging field called nanoinformatics to the field of precision medicine. This review also recapitulates how nanoinformatics could hasten the development of personalized nanomedicine for cancer, which is undoubtedly the need of the hour.
This approach has been facilitated by a humongous impending field named Nanoinformatics. These breakthroughs and advances have provided insight into the future of personalized medicine. Imperatively, they have been enabling landmark research to merge all advances, creating nanosized particles that contain drugs targeting cell surface receptors and other potent molecules designed to kill cancerous cells. Nanoparticle- based medicine has been developing and has become a center of attention in recent years, focusing primely on proficient delivery systems for various chemotherapy drugs.
尽管在过去几十年中，人类在对抗最致命的疾病之一——癌症方面取得了显著进展，生存率也有了显著提高，但寻找终极治愈方法仍然是一种乌托邦式的幻想。纳米信息学是生物信息学与纳米技术的结合，为癌症治疗中个性化纳米药物载体的临床前和临床开发带来了许多新的研究机会。个性化纳米药物由于其非侵入性和新颖的治疗方法，有望成为癌症治疗的一种有前途的治疗选择。具体来说，由于其多功能性，即能够根据患者群体调整药物，个性化医学领域有望很快产生巨大影响。
本综述解释了这个新兴领域纳米信息学在精准医学领域的应用。本文还回顾了纳米信息学如何加速癌症个性化纳米医学的发展，这无疑是当前的迫切需求。
这种方法得益于一个名为纳米信息学的庞大新兴领域。这些突破和进展为个性化医学的未来提供了新的思路。至关重要的是，它们使得各种先进技术能够融合，创造出载有针对细胞表面受体和其他强效分子的药物的纳米颗粒，这些分子旨在杀死癌细胞。基于纳米粒子的药物在近年来得到了发展，并成为关注的焦点，主要集中在各种化疗药物的高效传递系统上。
