Lovlin R, Cottle W, Pyke I, Kavanagh M, Belcastro A N
Eur J Appl Physiol Occup Physiol. 1987;56(3):313-6. doi: 10.1007/BF00690898.
The possibility that plasma levels of malonaldehyde (MDA) are altered by exercise has been examined. The presence of MDA has been recognized to reflect peroxidation of lipids resulting from reactions with free radicals. Maximal exercise, eliciting 100% of maximal oxygen consumption (VO2max) resulted in a 26% increase in plasma MDA (P less than 0.005). Short periods of intermittent exercise, the intensity of which was varied, indicated a correlation between lactate and MDA (r2 = 0.51) (p less than 0.001). Blood lactate concentrations increased throughout this exercise regimen. A significant decrease (10.3%) in plasma MDA occurred at 40% VO2max. At 70% VO2max plasma MDA was still below resting values, however the trend to an increase in MDA with exercise intensity was evident. At exhaustion, plasma MDA and lactate were significantly greater than at rest. These results suggest, that exhaustive maximal exercise induces free radical generation while short periods of submaximal exercise (i.e. less than 70% VO2max) may inhibit it and lipid peroxidation.
研究了运动是否会改变血浆丙二醛（MDA）水平。人们已经认识到MDA的存在反映了与自由基反应导致的脂质过氧化。引发最大摄氧量（VO2max）100%的最大运动导致血浆MDA增加26%（P<0.005）。短时间的间歇运动，其强度有所变化，表明乳酸与MDA之间存在相关性（r2 = 0.51）（P<0.001）。在整个运动方案中，血乳酸浓度都有所增加。在VO2max为40%时，血浆MDA显著下降（10.3%）。在VO2max为70%时，血浆MDA仍低于静息值，然而，MDA随运动强度增加的趋势是明显的。在力竭时，血浆MDA和乳酸显著高于静息时。这些结果表明，力竭性最大运动诱导自由基生成，而短时间的次最大运动（即低于VO2max的70%）可能会抑制自由基生成和脂质过氧化。
