Lin Min, Luo Renwei, Zhang Peng, Xiao Zhixun, Gong Ting, Ji Chao
Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Central Laboratory, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Front Med (Lausanne). 2022 May 25;9:907345. doi: 10.3389/fmed.2022.907345. eCollection 2022.
Kaposi's Sarcoma (KS) is a neoplasm derived from endothelial cells and is associated with human herpesvirus-8 (HHV-8) infection. It is mostly seen in patients suffering from AIDS and/or chronic immunosuppression. Currently, systemic chemotherapy is the primary treatment option for the advanced KS. However, there is no consensus on the treatment of KS. In this case, an 84-year-old man with a history of psoriasis developed multiple painful dark purple nodules on the trunk and extremities during the treatment of drug reaction with eosinophilia and systemic symptoms (DRESS). KS was confirmed by the skin biopsy, and the immunohistochemical staining demonstrated the positivity for HHV-8 while the anti-HIV test was negative. The patient then received anlotinib treatment, a tyrosine kinase inhibitor, for 5 months, and his skin lesions subsided. This case indicates that anlotinib may be a potential treatment option for KS.
卡波西肉瘤（KS）是一种起源于内皮细胞的肿瘤，与人类疱疹病毒8型（HHV-8）感染相关。它多见于艾滋病患者和/或慢性免疫抑制患者。目前，全身化疗是晚期KS的主要治疗选择。然而，对于KS的治疗尚无共识。在此病例中，一名有银屑病病史的84岁男性在药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）治疗期间，躯干和四肢出现多个疼痛性暗紫色结节。皮肤活检确诊为KS，免疫组化染色显示HHV-8阳性，而抗HIV检测为阴性。该患者随后接受酪氨酸激酶抑制剂安罗替尼治疗5个月，皮肤病变消退。此病例表明安罗替尼可能是KS的一种潜在治疗选择。
