卡波西肉瘤的电化学疗法：一项系统评价。
Electrochemotherapy in Kaposi sarcoma: A systematic review.
作者信息
Ferioli Martina, Galuppi Andrea, Buwenge Milly, Cammelli Silvia, Perrone Anna Myriam, Macchia Gabriella, Deodato Francesco, Cilla Savino, Zamagni Alice, De Terlizzi Francesca, Tagliaferri Luca, De Iaco Pierandrea, Morganti Alessio Giuseppe
机构信息
Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, I-40138 Bologna, Italy.
Oncologic Gynaecology Unit, Department Medical and Surgical Sciences (DIMEC), University of Bologna, S. Orsola-Malpighi Hospital, I-40138 Bologna, Italy.
出版信息
Mol Clin Oncol. 2021 Apr;14(4):64. doi: 10.3892/mco.2021.2226. Epub 2021 Feb 8.
Kaposi sarcoma (KS) is a rare angioproliferative disorder, which is usually associated with human herpesvirus-8 infection. Electrochemotherapy (ECT) may be an option in the treatment of KS skin lesions due to the high response rate noted in neoplastic lesions of different histological types. The aim of the present systematic review was to analyse the available evidence on using ECT in the treatment of KS skin lesions. Tumor response, local control and toxicity were analyzed. In the three included studies, the complete response rate was 65-100% and the overall response rate in all studies was 100%. The treatment was well tolerated with mild and transient toxicity. However, further studies are required to fully analyze long-term disease control and to compare ECT with other local therapies used for KS.
卡波西肉瘤（KS）是一种罕见的血管增殖性疾病，通常与人类疱疹病毒8型感染有关。由于在不同组织学类型的肿瘤性病变中观察到较高的缓解率，电化学疗法（ECT）可能是治疗KS皮肤病变的一种选择。本系统评价的目的是分析使用ECT治疗KS皮肤病变的现有证据。分析了肿瘤反应、局部控制和毒性。在纳入的三项研究中，完全缓解率为65%-100%，所有研究的总缓解率为100%。该治疗耐受性良好，毒性轻微且短暂。然而，需要进一步研究以全面分析长期疾病控制情况，并将ECT与用于KS的其他局部治疗方法进行比较。
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