Shi Lijuan, Han Shuai, Zhao Jian, Kuang Zhejun, Jing Weipeng, Cui Yuqing, Zhu Zhanpeng
College of Electronic Information Engineering, Changchun University, Changchun, China.
Jilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement, Changchun, China.
Front Oncol. 2022 May 27;12:884523. doi: 10.3389/fonc.2022.884523. eCollection 2022.
Radiotherapy is one of the important treatments for malignant tumors. The precision of radiotherapy is affected by the respiratory motion of human body, so real-time motion tracking for thoracoabdominal tumors is of great significance to improve the efficacy of radiotherapy. This paper aims to establish a highly precise and efficient prediction model, thus proposing to apply a depth prediction model composed of multi-scale enhanced convolution neural network and temporal convolutional network based on empirical mode decomposition (EMD) in respiratory prediction with different delay times. First, to enhance the precision, the unstable original sequence is decomposed into several intrinsic mode functions (IMFs) by EMD, and then, a depth prediction model of parallel enhanced convolution structure and temporal convolutional network with the characteristics specific to IMFs is built, and finally training on the respiratory motion dataset of 103 patients with malignant tumors is conducted. The prediction precision and time efficiency of the model are compared at different levels with those of the other three depth prediction models so as to evaluate the performance of the model. The result shows that the respiratory motion prediction model determined in this paper has superior prediction performance under different lengths of input data and delay time, and, furthermore, the network update time is shortened by about 60%. The method proposed in this paper will greatly improve the precision of radiotherapy and shorten the radiotherapy time, which is of great application value.
放射治疗是恶性肿瘤的重要治疗手段之一。放射治疗的精度受人体呼吸运动影响,因此对胸腹部肿瘤进行实时运动跟踪对于提高放射治疗疗效具有重要意义。本文旨在建立一个高精度、高效率的预测模型,为此提出在不同延迟时间的呼吸预测中应用基于经验模态分解(EMD)的多尺度增强卷积神经网络和时间卷积网络组成的深度预测模型。首先,为提高精度,通过EMD将不稳定的原始序列分解为若干固有模态函数(IMF),然后构建具有IMF特定特征的并行增强卷积结构和时间卷积网络的深度预测模型,最后在103例恶性肿瘤患者的呼吸运动数据集上进行训练。将该模型在不同水平下的预测精度和时间效率与其他三种深度预测模型进行比较,以评估该模型的性能。结果表明,本文确定的呼吸运动预测模型在不同输入数据长度和延迟时间下具有优越的预测性能,此外,网络更新时间缩短了约60%。本文提出的方法将大大提高放射治疗的精度,缩短放射治疗时间,具有重要的应用价值。