β-干扰素可诱导培养的人癌细胞产生纤溶酶原激活物。
Interferon-beta can induce the production of plasminogen activator by cultured human cancer cells.
作者信息
Karai M, Namba M
出版信息
Experientia. 1987 Apr 15;43(4):435-7. doi: 10.1007/BF01940443.
PMID:3569495
Abstract
Three cultured human cell lines, renal cancer cells (ACHN), bladder cancer cells (EJ), and fibroblasts transformed in culture by Co-60 gamma rays (KMST-6), when treated with interferon-beta, produced 1.5 to 4 times as much plasminogen activator as the untreated control cultures. This enhanced production of PA was inhibited by cycloheximide or actinomycin D.
摘要
三种培养的人细胞系，即肾癌细胞（ACHN）、膀胱癌细胞（EJ）以及经钴 - 60γ射线体外转化的成纤维细胞（KMST - 6），在用β干扰素处理时，产生的纤溶酶原激活物是未处理的对照培养物的1.5至4倍。这种纤溶酶原激活物产量的增加受到放线菌酮或放线菌素D的抑制。
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