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β-干扰素可诱导培养的人癌细胞产生纤溶酶原激活物。

Interferon-beta can induce the production of plasminogen activator by cultured human cancer cells.

作者信息

Karai M, Namba M

出版信息

Experientia. 1987 Apr 15;43(4):435-7. doi: 10.1007/BF01940443.

DOI:10.1007/BF01940443
PMID:3569495
Abstract

Three cultured human cell lines, renal cancer cells (ACHN), bladder cancer cells (EJ), and fibroblasts transformed in culture by Co-60 gamma rays (KMST-6), when treated with interferon-beta, produced 1.5 to 4 times as much plasminogen activator as the untreated control cultures. This enhanced production of PA was inhibited by cycloheximide or actinomycin D.

摘要

三种培养的人细胞系,即肾癌细胞(ACHN)、膀胱癌细胞(EJ)以及经钴 - 60γ射线体外转化的成纤维细胞(KMST - 6),在用β干扰素处理时,产生的纤溶酶原激活物是未处理的对照培养物的1.5至4倍。这种纤溶酶原激活物产量的增加受到放线菌酮或放线菌素D的抑制。

相似文献

1
Interferon-beta can induce the production of plasminogen activator by cultured human cancer cells.β-干扰素可诱导培养的人癌细胞产生纤溶酶原激活物。
Experientia. 1987 Apr 15;43(4):435-7. doi: 10.1007/BF01940443.
2
Concanavalin A stimulation of plasminogen activator production in pig kidney cells in culture.伴刀豆球蛋白A对培养的猪肾细胞中纤溶酶原激活物产生的刺激作用。
Biochim Biophys Acta. 1979 Dec 3;588(2):273-78. doi: 10.1016/0304-4165(79)90210-1.
3
Production of a cell-associated and secreted plasminogen activator by cultured rat granulosa cells.培养的大鼠颗粒细胞产生细胞相关和分泌型纤溶酶原激活物。
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4
Modulation of mRNA levels for urinary- and tissue-type plasminogen activator and plasminogen activator inhibitors 1 and 2 in human fibroblasts by interleukin 1.白细胞介素1对人成纤维细胞中尿激酶型和组织型纤溶酶原激活物以及纤溶酶原激活物抑制剂1和2的mRNA水平的调节作用。
J Immunol. 1989 Aug 1;143(3):890-5.
5
Intracellular plasminogen activator activity in growing and quiescent cells.生长细胞与静止细胞中的细胞内纤溶酶原激活物活性
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Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts.转化生长因子β刺激人滑膜成纤维细胞中的尿激酶型纤溶酶原激活物和DNA合成,但不刺激前列腺素E2的产生。
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Production of plasminogen activator by established cell lines of mouse origin.源自小鼠的已建细胞系产生纤溶酶原激活物。
J Cell Biol. 1977 Apr;73(1):47-55. doi: 10.1083/jcb.73.1.47.

本文引用的文献

1
Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.悬浮L细胞中病毒干扰的定量研究。III. 干扰病毒和干扰素对细胞生长速率的影响。
Virology. 1962 Jun;17:324-34. doi: 10.1016/0042-6822(62)90123-x.
2
Virus interference. I. The interferon.病毒干扰。一、干扰素。
Proc R Soc Lond B Biol Sci. 1957 Sep 12;147(927):258-67. doi: 10.1098/rspb.1957.0048.
3
Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines.
B16小鼠黑色素瘤细胞系中纤溶酶原激活物的产生与肿瘤转移的相关性。
Cancer Res. 1980 Feb;40(2):288-92.
4
Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity.具有免疫干扰素活性的淋巴因子对小鼠巨噬细胞Ia抗原表达的调节。
J Exp Med. 1982 Dec 1;156(6):1780-93. doi: 10.1084/jem.156.6.1780.
5
Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment.重组人白细胞α-干扰素治疗后,人乳腺和结肠肿瘤细胞表面肿瘤相关抗原的表达增强。
Cancer Res. 1984 Aug;44(8):3208-14.
6
Differential growth response of normal human diploid fibroblasts and in vitro transformed human fibroblasts in serum-free defined culture medium.正常人二倍体成纤维细胞和体外转化的人成纤维细胞在无血清限定培养基中的差异生长反应。
Int J Cancer. 1984 Nov 15;34(5):645-9. doi: 10.1002/ijc.2910340510.
7
The role of interferon-gamma in induction of differentiation of human myeloid leukemia cell lines, ML-1 and HL-60.干扰素-γ在诱导人髓系白血病细胞系ML-1和HL-60分化中的作用。
Biochem Biophys Res Commun. 1984 Oct 15;124(1):100-5. doi: 10.1016/0006-291x(84)90922-7.
8
Mouse immune interferon enhances fibronectin production of elicited macrophages.小鼠免疫干扰素可增强诱导巨噬细胞的纤连蛋白生成。
J Immunol. 1984 Dec;133(6):3102-6.
9
Antibodies to plasminogen activator inhibit human tumor metastasis.纤溶酶原激活物抗体可抑制人类肿瘤转移。
Cell. 1983 Dec;35(3 Pt 2):611-9. doi: 10.1016/0092-8674(83)90093-4.
10
Tumor invasion and host extracellular matrix.肿瘤侵袭与宿主细胞外基质。
Cancer Metastasis Rev. 1983;2(2):129-52. doi: 10.1007/BF00048966.