伴刀豆球蛋白A对培养的猪肾细胞中纤溶酶原激活物产生的刺激作用。

Concanavalin A stimulation of plasminogen activator production in pig kidney cells in culture.

作者信息

Mochan E

出版信息

Biochim Biophys Acta. 1979 Dec 3;588(2):273-78. doi: 10.1016/0304-4165(79)90210-1.

Abstract

Addition of subtoxic doses of the lectin concanavalin A to growing subconfluent monolayer cultures of pig kidney cells causes an increase in extra- and intracellular plasminogen activator activity which is reversibly inhibited by actinomycin D, cycloheximide and alpha-methyl-D-mannoside. These results suggest that cell surface events may play an important modulatory role in plasminogen activator production.

摘要

向猪肾细胞生长的亚汇合单层培养物中添加亚毒性剂量的伴刀豆球蛋白A，会导致细胞外和细胞内纤溶酶原激活物活性增加，而放线菌素D、环己酰亚胺和α-甲基-D-甘露糖苷可对其进行可逆性抑制。这些结果表明，细胞表面事件可能在纤溶酶原激活物的产生中发挥重要的调节作用。