Tian Yuting, Zhao Rong, Xiao Shili, Chen Lu, Cheng Yi, Meng Wei, Tang Zongyuan, Cai Yi, Xiao Zhifeng, Yi Ailin, Chen Minjia, Zhao Xuefei, Ruan Guangcong, Wei Yanling
Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Cell Infect Microbiol. 2025 Mar 27;15:1524987. doi: 10.3389/fcimb.2025.1524987. eCollection 2025.
The interaction between the host and microbiota is influenced by host circadian rhythm. However, it is unknown what the changes of gut microbiota and metabolites.
We conducted a cross-sectional study (n=72) in which participants' fecal DNA was detected by macrogenomic sequencing analysis. The feces, urine and blood were analyzed by widely targeted metabolomics analysis.
Pearson correlation analysis showed that most of the clinical symptoms of people with circadian rhythm disorders were moderately positively correlated with gastrointestinal symptoms. By distilling the results of multinomic analysis, we reported a variety of different species (19 species in the gut) and metabolites. In our results, the correlation of multiomics is mostly concentrated in and . Bile acid-related metabolites are the most significant metabolites associated with these species.
Our study demonstrates the severity of clinical manifestations caused by circadian rhythm disorder is closely related to microbiota and metabolism. In the future, personalized interventions targeting specific microbial species or metabolites may help alleviate the physical and psychological discomfort induced by circadian rhythm disturbances.
宿主与微生物群之间的相互作用受宿主昼夜节律影响。然而，肠道微生物群和代谢产物的变化情况尚不清楚。
我们开展了一项横断面研究（n = 72），通过宏基因组测序分析检测参与者的粪便DNA。采用广泛靶向代谢组学分析对粪便、尿液和血液进行分析。
Pearson相关性分析表明，昼夜节律紊乱人群的大多数临床症状与胃肠道症状呈中度正相关。通过提炼多组学分析结果，我们报告了多种不同的物种（肠道中有19种）和代谢产物。在我们的结果中，多组学的相关性大多集中在……和……。胆汁酸相关代谢产物是与这些物种相关的最显著代谢产物。
我们的研究表明，昼夜节律紊乱引起的临床表现严重程度与微生物群和代谢密切相关。未来，针对特定微生物物种或代谢产物的个性化干预措施可能有助于减轻昼夜节律紊乱引起的身心不适。
