Paerewijck Oonagh, Lamkanfi Mohamed
Laboratory of Medical Immunology, Department of Internal Medicine and Paediatrics, Ghent University, Ghent, B-9000, Belgium.
Laboratory of Medical Immunology, Department of Internal Medicine and Paediatrics, Ghent University, Ghent, B-9000, Belgium.
Mol Aspects Med. 2022 Dec;88:101100. doi: 10.1016/j.mam.2022.101100. Epub 2022 Jun 10.
Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and their regulation mechanisms, including an expansion of inflammasome biology to adaptive immune cells. These exciting developments in basic research have been accompanied by potentially transformative results from large clinical trials and translational efforts to develop inflammasome-targeted small molecule inhibitors for therapeutic use. Here, we will discuss recent findings in the field with a specific emphasis on activation mechanisms of human inflammasomes and their potential role in auto-inflammatory, metabolic and neoplastic diseases.
二十年来对炎性小体的研究已产生了大量知识，涉及在主要源自啮齿动物的众多研究模型中经典和非经典炎性小体激活的复杂调控机制及病理作用。最近，该领域在表征人类特异性炎性小体及其调控机制方面取得了显著进展，包括将炎性小体生物学扩展到适应性免疫细胞。基础研究中的这些激动人心的进展伴随着大型临床试验的潜在变革性结果以及开发用于治疗的炎性小体靶向小分子抑制剂的转化研究努力。在此，我们将讨论该领域的最新发现，特别强调人类炎性小体的激活机制及其在自身炎症性、代谢性和肿瘤性疾病中的潜在作用。
