State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Department of Electrical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong.
Nat Commun. 2022 Jun 13;13(1):3384. doi: 10.1038/s41467-022-31106-9.
Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets. Importantly, the defect-rich CoMo-LDH nanosheets exhibit much higher activity (~97 times) for generation of reactive oxygen species than that of the pristine CoMo-LDH nanosheets under a NIR-III 1567 nm laser irradiation. Therefore, after modification with polyethylene glycol, the defect-rich CoMo-LDH nanosheets can be used as an efficient inorganic PS for PDT to efficiently induce cancer cells apoptosis in vitro and eradicate tumors in vivo under 1567 nm laser irradiation.
虽然二维（2D）层状双氢氧化物（LDHs）已被广泛用作生物诊断和治疗的高效纳米试剂，但它们作为光动力治疗（PDT）的光敏剂（PS），其活性较低。在此，我们报告了超薄 2D CoMo-LDH 和 NiMo-LDH 纳米片的缺陷工程，将其作为在近红外 III 区（NIR-III）的高效无机 PS 用于 PDT。通过简单的酸处理，水热合成的 2D CoMo-LDH 和 NiMo-LDH 纳米片被刻蚀，得到富含缺陷的 CoMo-LDH 和 NiMo-LDH 纳米片。重要的是，富含缺陷的 CoMo-LDH 纳米片在 NIR-III 1567nm 激光照射下产生活性氧的活性（~97 倍）明显高于原始 CoMo-LDH 纳米片。因此，经过聚乙二醇修饰后，富含缺陷的 CoMo-LDH 纳米片可用作高效的无机 PS 用于 PDT，在 1567nm 激光照射下可有效诱导体外癌细胞凋亡并在体内消除肿瘤。
