Gui Haoguan, Yang Tiantian, Li Li-Li, Liang Fuxin, Yang Zhenzhong
Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou 213164, China.
ACS Nano. 2022 Jun 28;16(6):9859-9870. doi: 10.1021/acsnano.2c03940. Epub 2022 Jun 14.
A fabrication strategy for multifunctional organohydrogels is proposed, which combines phase-change microinclusions within a double-network (DN) hydrogel under the stabilization of Janus particles. Janus particles possess reactivity and colloidal stability for more robust organohydrogels, while the interstice among Janus particles enhances the mass transfer between the phase interfaces. Moreover, DN hydrogels are achieved through dynamic cross-linking networks, endowing organohydrogels with injectability and self-healing performance. Phase-change microinclusions are beneficial to the organohydrogels with temperature-responsive mechanical property and temperature-programed shape-memory performance. Organohydrogels can be employed for temperature therapy through the melting-crystallization process of phase-change microinclusions. Simultaneously, the payloads within microinclusions can be released for antibacteria upon melting the encapsulated wax. The organohydrogels can be served as an ideal dressing with temperature-responsive mechanical property, temperature therapy effectiveness, and temperature-triggered antibacterial ability.
提出了一种多功能有机水凝胶的制备策略，该策略在Janus颗粒的稳定作用下，将相变微内含物结合在双网络（DN）水凝胶中。Janus颗粒具有反应活性和胶体稳定性，可形成更坚固的有机水凝胶，而Janus颗粒之间的空隙增强了相界面之间的传质。此外，DN水凝胶通过动态交联网络实现，赋予有机水凝胶可注射性和自愈性能。相变微内含物有利于有机水凝胶具有温度响应机械性能和温度编程形状记忆性能。有机水凝胶可通过相变微内含物的熔融-结晶过程用于温度治疗。同时，微内含物中的有效载荷在包裹的蜡熔化时可释放用于抗菌。该有机水凝胶可作为一种具有温度响应机械性能、温度治疗效果和温度触发抗菌能力的理想敷料。
