Liu Jia
Henan Center for Disease Control and Prevention, Zhengzhou, China.
JMIR Res Protoc. 2022 Jun 13;11(6):e37133. doi: 10.2196/37133.
The HIV epidemic imposes a heavy burden on societal development. Protection of susceptible populations is the most feasible method for eliminating the spread of HIV. In the absence of a biological vaccine, the definitive solution is enabling susceptible populations to recognize and avoid high-risk sexual behavior.
The objective of this study is to use specific technologies and strategies to establish a system by which high-HIV-risk individuals can determine the HIV infection status of one another anonymously, conveniently, and credibly.
This study proposes an HIV digital vaccine (HDV) strategy, a decentralized application (Dapp) based on blockchain for use by individuals with a high risk of HIV and accredited testing agencies (ATAs). Following testing, only the HIV-negative results (or linked information) are uploaded to the blockchain, which results in high-risk individuals being able to determine the HIV-negative status of each other anonymously, conveniently, and credibly.
Future work includes the following: (1) a survey of the willingness to use Dapps among high-HIV-risk populations, (2) a larger framework containing both HDV and people living with HIV (PLH) and discussing the influence of HDV on PLH and its possible solutions, and (3) coordinating with the blockchain development team, ATAs, community-based organizations, and third-party organizations to raise funds, develop the Dapp, formulate detailed plans, and publicize and promote it. The exact timeline for achieving these objectives cannot be determined at present.
The HDV strategy may reduce the occurrence of high-risk sexual behavior and effectively protect susceptible populations; combined with current strategies, it is a promising solution to prevent the spread of HIV. The included concepts of decentralized surveillance and surveillance as intervention may spark a change in current infectious disease prevention and control modes to introduce beneficial innovations in public health systems globally.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/37133.
艾滋病流行给社会发展带来沉重负担。保护易感人群是消除艾滋病传播的最可行方法。在缺乏生物疫苗的情况下，最终解决方案是使易感人群能够识别并避免高风险性行为。
本研究的目的是使用特定技术和策略建立一个系统，使艾滋病高风险个体能够方便、可靠且匿名地相互确定艾滋病感染状况。
本研究提出一种艾滋病数字疫苗（HDV）策略，即基于区块链的去中心化应用程序（Dapp），供艾滋病高风险个体和经认可的检测机构（ATA）使用。检测后，仅将艾滋病阴性结果（或相关信息）上传至区块链，这使得高风险个体能够方便、可靠且匿名地相互确定对方的艾滋病阴性状态。
未来工作包括：（1）对艾滋病高风险人群使用Dapp的意愿进行调查；（2）构建一个包含HDV和艾滋病感染者（PLH）的更大框架，并讨论HDV对PLH的影响及其可能的解决方案；（3）与区块链开发团队、ATA、社区组织和第三方组织协调，筹集资金、开发Dapp、制定详细计划并进行宣传推广。目前无法确定实现这些目标的确切时间表。
HDV策略可能减少高风险性行为的发生，有效保护易感人群；与当前策略相结合，是预防艾滋病传播的一个有前景的解决方案。所包含的去中心化监测和监测即干预的概念可能引发当前传染病预防和控制模式的变革，从而在全球公共卫生系统中引入有益的创新。
国际注册报告识别码（IRRID）：PRR1-10.2196/37133
