1Department Of Clinical and Laboratory Science, College of Pharmacy, University of Basrah, Iraq.
2Department of Surgery, Al-Sader Teaching Hospital, Basrah Medical college, University of Basrah, Iraq.
Georgian Med News. 2024 Feb(347):168-176.
The idea that obesity and cardiovascular diseases together are considered for a sizable share of adult global morbidity and mortality is supported by epidemiological data. They have intricate systems in which environmental and genetic variables interact, including nutrition. As an environmental component, nutrition has a major and well-known role in managing health and preventing obesity and disorders connected to obesity, such as cardiovascular disease (CVD). Nonetheless, people with the same food pattern but obese exhibit a notable difference in CVD. This variance might be explained by the various genetic polymorphisms which gave rise to the field of nutrigenetics. The discipline known as nutritional genomics, or nutrigenetics, examines and describes gene variants linked to varying reactions to particular nutrients and links these variations to various disorders, including obesity-related cardiovascular disease (CVD). Therefore, tailored nutrition advice depending on a person's genetic background could enhance the results of a particular dietary intervention and offer a novel dietary technique to enhance health by lowering obesity and cardiovascular disease. With these suppositions, it seems reasonable to assume that understanding food and gene interactions will provide more targeted and efficacious dietary treatments in preventing obesity and CVD by nutrigenetics-based personalized nutrition. In addition to elucidating the connection between diet and gene expression and the major nutrition-related genes involved in obesity and CVD, this research seeks to provide a concise summary of the greater significant genes linked to obesity and CVD.
肥胖症和心血管疾病被认为是导致全球成年人群发病率和死亡率的重要因素，这一观点得到了流行病学数据的支持。这些疾病存在着复杂的系统，其中环境和遗传因素相互作用，包括营养。作为环境因素的一部分，营养在管理健康和预防肥胖以及与肥胖相关的疾病（如心血管疾病）方面起着重要而众所周知的作用。然而，具有相同饮食模式但肥胖的人群在心血管疾病方面表现出明显的差异。这种差异可以用遗传多态性来解释，这就产生了营养遗传学领域。营养基因组学或营养遗传学这一学科研究并描述了与特定营养素的不同反应相关的基因变异，并将这些变异与各种疾病联系起来，包括与肥胖相关的心血管疾病。因此，根据个人的遗传背景提供个性化的营养建议，可以增强特定饮食干预的效果，并提供一种通过降低肥胖和心血管疾病来改善健康的新的饮食方法。基于这些假设，我们有理由认为，通过基于营养遗传学的个性化营养来理解食物和基因的相互作用，将为预防肥胖症和心血管疾病提供更有针对性和更有效的饮食治疗方法。除了阐明饮食与基因表达之间的联系以及与肥胖和心血管疾病相关的主要营养相关基因外，本研究还旨在提供与肥胖和心血管疾病相关的更大意义的基因的简明总结。
