Li Xiaoxue, Diviant Jegason P, Stith Sarah S, Brockelman Franco, Keeling Keenan, Hall Branden, Vigil Jacob M
Department of Economics, University of New Mexico, Albuquerque, New Mexico, USA.
Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.
Med Cannabis Cannabinoids. 2022 Apr 13;5(1):76-84. doi: 10.1159/000524057. eCollection 2022.
We measure for the first time how commercially available flower products affect feelings of fatigue.
A total of 1,224 people recorded 3,922 flower self-administration sessions between June 6, 2016, and August 7, 2019, using the Releaf App. Usage sessions included real-time subjective changes in fatigue intensity levels prior to and following consumption, flower characteristics (labeled phenotype, cannabinoid potency levels), combustion method, and any potential experienced side effects.
On average, 91.94% of people experienced decreased fatigue following consumption with an average symptom intensity reduction of 3.48 points on a 0-10 visual analog scale (SD = 2.70, = 1.60, < 0.001). While labeled plant phenotypes ("," "," or "hybrid") did not differ in symptom relief, people that used joints to combust the flower reported greater symptom relief than pipe or vaporizer users. Across cannabinoid levels, tetrahydrocannabinol, and cannabidiol levels were generally not associated with changes in symptom intensity levels. use was associated with several negative side effects that correspond to increased feelings of fatigue (e.g., feeling unmotivated, couch-locked) among a minority of users (<24% of users), with slightly more users (up to 37%) experiencing a positive side effect that corresponds to increased energy (e.g., feeling active, energetic, frisky, or productive).
The findings suggest that the majority of patients experience decreased fatigue from consumption of flower consumed in vivo, although the magnitude of the effect and extent of side effects experienced likely vary with individuals' metabolic states and the synergistic chemotypic properties of the plant.
我们首次测量市售花卉产品如何影响疲劳感。
2016年6月6日至2019年8月7日期间，共有1224人使用Releaf应用程序记录了3922次花卉自我服用过程。服用过程包括服用前后疲劳强度水平的实时主观变化、花卉特征（标记的表型、大麻素效力水平）、燃烧方法以及任何可能出现的副作用。
平均而言，91.94%的人在服用后疲劳感减轻，在0至10的视觉模拟量表上症状强度平均降低3.48分（标准差=2.70，平均值=1.60，P<0.001）。虽然标记的植物表型（“”、“”或“杂交种”）在症状缓解方面没有差异，但使用卷烟吸食花卉的人比使用烟斗或蒸发器的人报告的症状缓解程度更大。在大麻素水平方面，四氢大麻酚和大麻二酚水平通常与症状强度水平的变化无关。使用与少数使用者（<24%的使用者）中一些与疲劳感增加相对应的负面副作用相关（例如，感觉缺乏动力、慵懒），有稍多一些使用者（高达37%）经历了与精力增加相对应的积极副作用（例如，感觉活跃、精力充沛、活泼或高效）。
研究结果表明，大多数患者在体内服用花卉后疲劳感减轻，尽管效果的大小和所经历副作用的程度可能因个体的代谢状态和植物的协同化学型特性而有所不同。
